%0 Journal Article %J Food Addit Contam Part A Chem Anal Control Expo Risk Assess %D 2017 %T Development and validation of a quantitative UHPLC-MS/MS method for selected brominated flame retardants in food. %A Svetlana V. Malysheva %A Séverine Goscinny %A Malarvannan, Govindan %A Poma, Giulia %A Mirjana Andjelkovic %A Voorspoels, Stefan %A Covaci, Adrian %A Joris Van Loco %K brominated flame retardants %K bromophenols %K Food Analysis %K HBCDsTBBPA %K UHPLC-MS/MS %X

An ultra-high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated (in-house) for the quantification of selected brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), hexabromocyclododecanes (HBCDs), tetrabromobisphenol S (TBBPS) and bromophenols (BPs), in various food matrices. The sample preparation consisted of extraction of TBBPS with acidified acetonitrile followed by a fast dispersive solid-phase extraction (dSPE) clean-up and extraction of the other BFRs with a mixture of hexane and dichloromethane (1:1, v/v) with subsequent clean-up using acidified silica (44%, w/w). The limits of quantification of the method varied widely for the types of food matrices and the different classes of BFRs from 4 pg g(-1) wet weight (ww) to 8 ng g(-1) ww. For most of the analytes the apparent recovery was in the range 70-120%, and the method precision (under repeatability conditions) was below 20%. The method was successfully applied in proficiency testing exercises as well as for analysis of various food items. Only 25% of the collected food samples contained BFRs, with 4-bromophenol and α-HBCD as the only detected compounds. The contaminated foodstuffs were fish and eggs with concentrations in the range from 48 to 305 pg g(-1) ww.

%B Food Addit Contam Part A Chem Anal Control Expo Risk Assess %8 2017 Oct 31 %G eng %R 10.1080/19440049.2017.1393110