<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aline Baldo</style></author><author><style face="normal" font="default" size="100%">Amaya Leunda</style></author><author><style face="normal" font="default" size="100%">Chuong Dai Do Thi</style></author><author><style face="normal" font="default" size="100%">Didier Breyer</style></author><author><style face="normal" font="default" size="100%">Katia Pauwels</style></author><author><style face="normal" font="default" size="100%">Sarah Welby</style></author><author><style face="normal" font="default" size="100%">Van Vaerenbergh, Bernadette</style></author><author><style face="normal" font="default" size="100%">Philippe Herman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Biosafety risk assessment and management of laboratory-derived influenza A (H5N1) viruses transmissible in ferrets</style></title><secondary-title><style face="normal" font="default" size="100%">Applied Biosafety</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">biosafety</style></keyword><keyword><style  face="normal" font="default" size="100%">Highly pathogenic avian influenza A (H5N1) virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Assessment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3/2013</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">17</style></number><volume><style face="normal" font="default" size="100%">18</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Highly pathogenic avian influenza (HPAI) A (H5N1) viruses
occasionally infect humans, but currently do not transmit efficiently
among them. However, the risk for human pandemic
influenza is a major concern should these viruses acquire the
capacity for human-to-human transmission and retain their
current virulence. Recently, two research teams have succeeded
in modifying HPAI A (H5N1) viruses in such a way that they
could be efficiently transmitted by respiratory route between
ferrets, the experimental model for studying influenza virus
transmission. In this article, the authors discuss the risk assessment
of these mutant HPAI A (H5N1) viruses in the context
of the European Union regulatory framework and recommend
that laboratory-derived HPAI A (H5N1) viruses transmissible
in ferrets should be handled in biosafety level 3 (BSL-3)
facilities with some additional biosafety measures.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><section><style face="normal" font="default" size="100%">6</style></section></record></records></xml>