<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Birgit Mertens</style></author><author><style face="normal" font="default" size="100%">Melissa Van Bossuyt</style></author><author><style face="normal" font="default" size="100%">Fraselle, S</style></author><author><style face="normal" font="default" size="100%">M N Blaude</style></author><author><style face="normal" font="default" size="100%">T Vanhaecke</style></author><author><style face="normal" font="default" size="100%">Rogiers, V</style></author><author><style face="normal" font="default" size="100%">Luc Verschaeve</style></author><author><style face="normal" font="default" size="100%">Els Van Hoeck</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Coatings in food contact materials: Potential source of genotoxic contaminants?</style></title><secondary-title><style face="normal" font="default" size="100%">Food Chem Toxicol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Food Chem Toxicol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Consumer Product Safety</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Contamination</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Packaging</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagenicity Tests</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagens</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Aug</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">505</style></number><volume><style face="normal" font="default" size="100%">106</style></volume><pages><style face="normal" font="default" size="100%">496-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Up till now, no harmonized EU regulation exists on chemicals used in coatings for food contact materials (FCM). Therefore, these substances need to comply with the general provisions of EU Regulation 1935/2004 and, if present, with national legislation. Different 'inventory lists' of compounds that might be present in coatings are available, but for hundreds of these substances, the potential human health impact of their use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health. First, an inventory was assembled containing all substances potentially used in coatings. Afterwards, the genotoxic potential of the non-evaluated substances was predicted in silico using two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non-FCM context and from the European CHemicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of the substances, additional toxicological information is needed.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">Pt A</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/28583787?dopt=Abstract</style></custom1><section><style face="normal" font="default" size="100%">496</style></section></record></records></xml>