<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarrazin, S</style></author><author><style face="normal" font="default" size="100%">Dewulf, J</style></author><author><style face="normal" font="default" size="100%">Elisabeth Mathijs</style></author><author><style face="normal" font="default" size="100%">Laureyns, J</style></author><author><style face="normal" font="default" size="100%">Laurent Mostin</style></author><author><style face="normal" font="default" size="100%">Ann Brigitte Cay</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Virulence comparison and quantification of horizontal bovine viral diarrhoea virus transmission following experimental infection in calves.</style></title><secondary-title><style face="normal" font="default" size="100%">Vet J</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Vet. J.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Belgium</style></keyword><keyword><style  face="normal" font="default" size="100%">Bovine Virus Diarrhea-Mucosal Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Cattle</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea Virus 1, Bovine Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea Virus 2, Bovine Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">virulence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Nov</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">202</style></volume><pages><style face="normal" font="default" size="100%">244-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Bovine viral diarrhoea virus (BVDV) causes persistent infections by infecting the fetus of susceptible animals during gestation. These persistently infected (PI) animals are important sources of infection. On the contrary, transiently infected (TI) animals are believed to be less important, but transient infections with a severe BVDV-2 strain can spread explosively. To assess the importance of TI cattle in the epidemiology of BVDV, two experimental infections were performed to determine basic reproduction ratios (R0). In each experiment three calves were infected via intranasal inoculation and housed together with seven susceptible animals. Two strains isolated in Belgium were used, a virulent BVDV-1b and a virulent BVDV-2a field isolate, resulting in an R0 of 0.25 (95% CI 0.01; 1.95) and 0.24 (95% CI 0.01; 2.11), respectively. A PI animal was then introduced to the remaining uninfected animals and produced an R of +∞ (95% CI 1.88; +∞). These results support the suggestion that TI animals, compared to PI animals, contribute only a limited amount to BVDV spread. Additionally, the severe clinical symptoms observed in the field with these isolates could not be reproduced during these experiments, suggesting that other factors besides strain virulence influence the clinical manifestations evoked by BVDV.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25201251?dopt=Abstract</style></custom1></record></records></xml>