<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Berdieke Goemaere</style></author><author><style face="normal" font="default" size="100%">Pierre Becker</style></author><author><style face="normal" font="default" size="100%">Van Wijngaerden, Eric</style></author><author><style face="normal" font="default" size="100%">Maertens, Johan</style></author><author><style face="normal" font="default" size="100%">Spriet, Isabel</style></author><author><style face="normal" font="default" size="100%">Marijke Hendrickx</style></author><author><style face="normal" font="default" size="100%">Lagrou, Katrien</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increasing candidemia incidence from 2004 to 2015 with a shift in epidemiology in patients pre-exposed to antifungals.</style></title><secondary-title><style face="normal" font="default" size="100%">Mycoses</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Mycoses</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Candida spp.</style></keyword><keyword><style  face="normal" font="default" size="100%">candidaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">incidence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Oct 12</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">7</style></number><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Candidemia is an important health problem in immunocompromised patients with an epidemiology varying with region, period and patient population involved.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;OBJECTIVES: &lt;/b&gt;The occurrence of candidemia and the associated species distribution over a 12-year period at a large tertiary care centre in Belgium were analysed. The trend in incidence in the intensive care units (ICUs) and non-ICUs was investigated as well as the influence of antifungal exposure on the species distribution.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;PATIENTS/METHODS: &lt;/b&gt;Candidemia incidence was expressed per 10,000 patient days (PD). Epidemiological parameters and antifungal consumption data were extracted from the hospital database and delivered by the hospital pharmacy, respectively.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;From 2004 until 2015, 865 candidemia episodes occurred in 826 patients at the University Hospitals Leuven. Candida albicans (59%) remained the most important cause of candidemia, followed by C. glabrata (22.4%) and C. parapsilosis (8%). The mean incidence in the whole hospital was 1.48 per 10,000 PD. The incidence in ICUs increased reaching up to 10.7 per 10,000 PD whereas in the non-ICUs, the incidence decreased. Prior exposure to fluconazole and echinocandins was associated with candidemia caused by less susceptible species.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;Candidemia incidence increased in the whole hospital, driven by ICUs. Surveillance of candidemia epidemiology on a local scale is of high value to guide empirical treatment strategies. This article is protected by copyright. All rights reserved.&lt;/p&gt;
</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/29024057?dopt=Abstract</style></custom1><section><style face="normal" font="default" size="100%">1</style></section></record></records></xml>