<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Julien R.C. Prevost</style></author><author><style face="normal" font="default" size="100%">Arina Kozlova</style></author><author><style face="normal" font="default" size="100%">Bouazza Es Saadi</style></author><author><style face="normal" font="default" size="100%">Esra Yildiz</style></author><author><style face="normal" font="default" size="100%">Sara Modaffari</style></author><author><style face="normal" font="default" size="100%">Didier M. Lambert</style></author><author><style face="normal" font="default" size="100%">Lionel Pochet</style></author><author><style face="normal" font="default" size="100%">Johan Wouters</style></author><author><style face="normal" font="default" size="100%">Eduard Dolušić</style></author><author><style face="normal" font="default" size="100%">Raphaël Frédérick</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors</style></title><secondary-title><style face="normal" font="default" size="100%">Tetrahedron Letters</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Electrophilic aromatic substitution</style></keyword><keyword><style  face="normal" font="default" size="100%">Halogenation</style></keyword><keyword><style  face="normal" font="default" size="100%">Monoacylglycerol lipase</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiazoles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan-12-2018</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">4319</style></number><volume><style face="normal" font="default" size="100%">59</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Highly functionalized 5-bromo-2-amino-1,3-thiazoles bearing various substituents could be easily prepared by a rapid and efficient one-pot method, using simple starting materials and mild conditions while avoiding the use of metal catalysts or inconvenient reagents such as elemental halogens. These useful products can serve as starting materials for other reactions or as pharmacologically interesting compounds. In our work we have shown that the resulting 5-bromothiazole compounds could lead to monoacylglycerol lipase (MAGL) inhibition in the μM range.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">49</style></issue><section><style face="normal" font="default" size="100%">4315</style></section></record></records></xml>