<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yinthe Dockx</style></author><author><style face="normal" font="default" size="100%">Esmée, Bijnens</style></author><author><style face="normal" font="default" size="100%">Nelly, Saenen</style></author><author><style face="normal" font="default" size="100%">Raf Aerts</style></author><author><style face="normal" font="default" size="100%">Jean-Marie, Aerts</style></author><author><style face="normal" font="default" size="100%">Lidia, Casas</style></author><author><style face="normal" font="default" size="100%">Andy, Delcloo</style></author><author><style face="normal" font="default" size="100%">Nicolas, Dendoncker</style></author><author><style face="normal" font="default" size="100%">Catherine, Linard</style></author><author><style face="normal" font="default" size="100%">Michelle, Plusquin</style></author><author><style face="normal" font="default" size="100%">Michiel, Stas</style></author><author><style face="normal" font="default" size="100%">An Van Nieuwenhuyse</style></author><author><style face="normal" font="default" size="100%">Jos, Van Orshoven</style></author><author><style face="normal" font="default" size="100%">Ben, Somers</style></author><author><style face="normal" font="default" size="100%">Tim, Nawrot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Residential green space in association with the methylation status in a CpG site within the promoter region of the placental serotonin receptor &lt;i&gt;HTR2A&lt;/i&gt;</style></title><secondary-title><style face="normal" font="default" size="100%">Epigenetics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aserotonin</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Methylation</style></keyword><keyword><style  face="normal" font="default" size="100%">epigenetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Green space</style></keyword><keyword><style  face="normal" font="default" size="100%">HTR2</style></keyword><keyword><style  face="normal" font="default" size="100%">Placenta</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-06-2022</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Green space could influence adult cognition and childhood neurodevelopment , and is hypothesized to be partly driven by epigenetic modifications. However, it remains unknown whether some of these associations are already evident during foetal development. Similar biological signals shape the developmental processes in the foetal brain and placenta.Therefore, we hypothesize that green space can modify epigenetic processes of cognition-related pathways in placental tissue, such as DNA-methylation of the serotonin receptor&amp;nbsp;HTR2A. HTR2A-methylation was determined within 327 placentas from the ENVIRONAGE (ENVIRonmental influence&amp;nbsp;ON&amp;nbsp;early AGEing) birth cohort using bisulphite-PCR-pyrosequencing. Total green space exposure was calculated using high-resolution land cover data derived from the Green Map of Flanders in seven buffers (50 m-3 km) and stratified into low (&amp;lt;3 m) and high (≥3 m) vegetation. Residential nature was calculated using the Land use Map of Flanders. We performed multivariate regression models adjusted for several&amp;nbsp;a priori&amp;nbsp;chosen covariables. For an IQR increment in total green space within a 1,000 m, 2,000 m and 3,000 m buffer the methylation of&amp;nbsp;HTR2A&amp;nbsp;increased with 1.47% (95%CI:0.17;2.78), 1.52% (95%CI:0.21;2.83) and 1.42% (95%CI:0.15;2.69), respectively. Additionally,, we found 3.00% (95%CI:1.09;4.91) and 1.98% (95%CI:0.28;3.68) higher&amp;nbsp;HTR2A-methylation when comparing residences with and without the presence of nature in a 50 m and 100 m buffer, respectively. The methylation status of&amp;nbsp;HTR2A&amp;nbsp;in placental tissue is positively associated with maternal green space exposure. Future research is needed to understand better how these epigenetic changes are related to functional modifications in the placenta and the consequent implications for foetal development.&lt;/p&gt;
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