<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kaat Schroven</style></author><author><style face="normal" font="default" size="100%">Leena Putzeys</style></author><author><style face="normal" font="default" size="100%">Alison Kerremans</style></author><author><style face="normal" font="default" size="100%">Pieter-Jan Ceyssens</style></author><author><style face="normal" font="default" size="100%">Marta Vallino</style></author><author><style face="normal" font="default" size="100%">Paeshuyse, Jan</style></author><author><style face="normal" font="default" size="100%">Farhana Haque</style></author><author><style face="normal" font="default" size="100%">Yusuf, Ahmed</style></author><author><style face="normal" font="default" size="100%">Matthias D Koch</style></author><author><style face="normal" font="default" size="100%">Lavigne, Rob</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The phage-encoded PIT4 protein affects multiple two-component systems of Pseudomonas aeruginosa</style></title><secondary-title><style face="normal" font="default" size="100%">Microbiol Spectr</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Nov 14</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;More and more isolates have become resistant to antibiotics like carbapenem. As a consequence, ranks in the top three of pathogens for which the development of novel antibiotics is the most crucial. The pathogen causes both acute and chronic infections, especially in patients who are the most vulnerable. Therefore, efforts are urgently needed to develop alternative therapies. One path explored in this article is the use of bacteriophages and, more specifically, phage-derived proteins. In this study, a phage-derived protein was studied that impacts key virulence factors of the pathogen via interaction with multiple histidine kinases of TCSs. The fundamental insights gained for this protein can therefore serve as inspiration for the development of an anti-virulence compound that targets the bacterial TCS.&lt;/p&gt;
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