<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wim L Cuypers</style></author><author><style face="normal" font="default" size="100%">Pieter Meysman</style></author><author><style face="normal" font="default" size="100%">Weill, François-Xavier</style></author><author><style face="normal" font="default" size="100%">Rene S Hendriksen</style></author><author><style face="normal" font="default" size="100%">Beyene, Getenet</style></author><author><style face="normal" font="default" size="100%">John Wain</style></author><author><style face="normal" font="default" size="100%">Satheesh Nair</style></author><author><style face="normal" font="default" size="100%">Marie A Chattaway</style></author><author><style face="normal" font="default" size="100%">Blanca M Perez-Sepulveda</style></author><author><style face="normal" font="default" size="100%">Pieter-Jan Ceyssens</style></author><author><style face="normal" font="default" size="100%">Tessa de Block</style></author><author><style face="normal" font="default" size="100%">Winnie W Y Lee</style></author><author><style face="normal" font="default" size="100%">Maria Pardos de la Gandara</style></author><author><style face="normal" font="default" size="100%">Kornschober, Christian</style></author><author><style face="normal" font="default" size="100%">Jacob Moran-Gilad</style></author><author><style face="normal" font="default" size="100%">Kees T Veldman</style></author><author><style face="normal" font="default" size="100%">Martin Cormican</style></author><author><style face="normal" font="default" size="100%">Torpdahl, Mia</style></author><author><style face="normal" font="default" size="100%">Patricia I Fields</style></author><author><style face="normal" font="default" size="100%">Tomáš Černý</style></author><author><style face="normal" font="default" size="100%">Liselotte Hardy</style></author><author><style face="normal" font="default" size="100%">Bieke Tack</style></author><author><style face="normal" font="default" size="100%">Kate C Mellor</style></author><author><style face="normal" font="default" size="100%">Nicholas Thomson</style></author><author><style face="normal" font="default" size="100%">Gordon Dougan</style></author><author><style face="normal" font="default" size="100%">Stijn Deborggraeve</style></author><author><style face="normal" font="default" size="100%">Jacobs, Jan</style></author><author><style face="normal" font="default" size="100%">Kris Laukens</style></author><author><style face="normal" font="default" size="100%">Sandra Van Puyvelde</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Commun</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-Bacterial Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Resistance, Bacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethiopia</style></keyword><keyword><style  face="normal" font="default" size="100%">Genomics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Salmonella</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Jun 14</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian adoptees, and occasional records exist of S. Concord linked to other countries. The evolution and geographical distribution of S. Concord remained unclear. Here, we provide a genomic overview of the population structure and antimicrobial resistance (AMR) of S. Concord by analysing genomes from 284 historical and contemporary isolates obtained between 1944 and 2022 across the globe. We demonstrate that S. Concord is a polyphyletic serovar distributed among three Salmonella super-lineages. Super-lineage A is composed of eight S. Concord lineages, of which four are associated with multiple countries and low levels of AMR. Other lineages are restricted to Ethiopia and horizontally acquired resistance to most antimicrobials used for treating invasive Salmonella infections in low- and middle-income countries. By reconstructing complete genomes for 10 representative strains, we demonstrate the presence of AMR markers integrated in structurally diverse IncHI2 and IncA/C2 plasmids, and/or the chromosome. Molecular surveillance of pathogens such as S. Concord supports the understanding of AMR and the multi-sector response to the global AMR threat. This study provides a comprehensive baseline data set essential for future molecular surveillance.&lt;/p&gt;
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