<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Indira Coenen</style></author><author><style face="normal" font="default" size="100%">Lotte Vander Elst</style></author><author><style face="normal" font="default" size="100%">Spriet, Isabel</style></author><author><style face="normal" font="default" size="100%">Matthias Gijsen</style></author><author><style face="normal" font="default" size="100%">Veerle Foulon</style></author><author><style face="normal" font="default" size="100%">Jan De Lepeleire</style></author><author><style face="normal" font="default" size="100%">Katrien Latour</style></author><author><style face="normal" font="default" size="100%">Veerle Cossey</style></author><author><style face="normal" font="default" size="100%">Schuermans, Annette</style></author><author><style face="normal" font="default" size="100%">Nele Stroobants</style></author><author><style face="normal" font="default" size="100%">Charlotte Quintens</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Check of APpropriaTeness of Antimicrobial therapy In Nursing homes (CAPTAIN): a point prevalence study in Belgium</style></title><secondary-title><style face="normal" font="default" size="100%">JAC-Antimicrobial Resistance</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">long-term care facilities; healthcare-associated infections; antimicrobial use</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar-07-2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Objectives&lt;/p&gt;

&lt;p&gt;The overall prevalence of antimicrobial therapy (AMT) in nursing homes is well described. However, less is known about the appropriateness of AMT in nursing home residents. Therefore, the Check of APpropriaTeness of antimicrobial therapy in nursing homes (CAPTAIN) study aimed to assess both prevalence and appropriateness of AMT in Belgian nursing homes.&lt;/p&gt;

&lt;p&gt;Methods&lt;/p&gt;

&lt;p&gt;In a prospective, observational, point prevalence study, researchers documented prevalence and identified potentially inappropriate prescriptions (PIPs) by evaluating accordance of AMT with national guidelines. The severity of inappropriateness was assessed by a modified Delphi expert panel.&lt;/p&gt;

&lt;p&gt;Results&lt;/p&gt;

&lt;p&gt;Eleven nursing homes, including 1178 residents, participated in this study. On the survey day, 8.0% of residents took systemic AMT, primarily for urinary tract infections (54.2%), respiratory tract infections (36.5%), and skin and skin-structure infections (6.3%). About half of these prescriptions were used in prophylaxis (52.1%). Registration of indication and stop date was missing in 58.3% and 56.3% of AMTs, respectively. In 89.6% of the systemic AMTs, at least one discordance with national guidelines was identified, resulting in a total of 171 PIPs, with 49 unique PIPs. Of all unique PIPs, 26.5% were assessed with a high severity score (≥4). According to the expert panel, most inappropriate practice was starting AMT for cough without other symptoms. Inappropriate timing of time-dependent AMTs was common, but assessed as ‘moderately severe’. One-third of systemic AMT exceeded the recommended duration.&lt;/p&gt;

&lt;p&gt;Conclusions&lt;/p&gt;

&lt;p&gt;AMT in nursing homes is often not prescribed according to national guidelines, highlighting the need for future interventions to promote the rational use of AMT in this setting.&lt;/p&gt;
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