Helminth-induced IL-4 expands bystander memory CD8 T cells for early control of viral infection.

Last updated on 22-8-2019 by Anonymous (niet gecontroleerd)

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Peer reviewed scientific article




Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8 T cells (T) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the T compartment. Here, we show that helminths expand CD44CD62LCXCR3CD49d T cells through direct IL-4 signaling in CD8 T cells. Importantly, helminth-mediated conditioning of T cells provided enhanced control of acute respiratory inf…

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