Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.

Last updated on 15-12-2021 by Cyril Barbezange

Public Access


Peer reviewed scientific article



Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A viruses are major human pathogens that are responsible for seasonal epidemics, but the interplay between viral proteins and cellular exonucleases has never been specifically studied. Here, using a stringent interactomics screening strategy and an siRNA-silencing approach, we identified eight cellular factors among a set of 75 cellular proteins carrying exo(ribo)nuclease activities or involved i…

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