Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

Peer reviewed scientific article





Rabies virus is a neurovirulent RNA virus, which causes about 59000 human deaths each year. Treatment for rabies does not exist due to incomplete understanding of the pathogenesis. MALT1 mediates activation of several immune cell types and is involved in the proliferation and survival of cancer cells. MALT1 acts as a scaffold protein for NF-κB signaling and a cysteine protease that cleaves substrates, leading to the expression of immunoregulatory genes. Here, we examined the impact of genetic or pharmacological MALT1 inhibition in mice on disease development after infection with the virulen…

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