Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules36549

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

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Peer reviewed scientific article

Samenvatting:

For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (Fusion protein), Rabies virus (Glycoprotein) and H5N1 Influenza (Hemagglutinin 5) were selected from llama derived immune libraries by phage display. Neutralizing VHH recognizing different epitopes in the receptor binding sites on the spikes with affinities in the low nanomolar range were identified for all the three viruses by viral neutra…

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