Regulation of Neurotoxin Expression by Culture Conditions.

Last updated on 24-1-2022 by Jill Alexandre

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BACKGROUND: Ensuring consistency of tetanus neurotoxin (TeNT) production by could help to ensure consistent product quality in tetanus vaccine manufacturing, ultimately contributing to reduced animal testing. The aim of this study was to identify RNA signatures related to consistent TeNT production using standard and non-standard culture conditions. METHODS: We applied RNA sequencing (RNA-Seq) to study gene expression in small-scale batches under several culture conditions. RESULTS: We identified 1381 time-dependent differentially expressed genes (DEGs) reflecting, among others, chang…

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