Scientific Opinion of the EFSA Panel on Plant Protection Products and their Residues (PPR) on Evaluation of the toxicological relevance of pesticide metabolites for dietary risk assessment

Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)

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Peer reviewed scientific article




The European Food Safety Authority (EFSA) asked the Panel on Plant Protection Products and theirResidues (PPR) to develop an opinion on approaches to evaluate the toxicological relevance ofmetabolites and degradates of pesticide active substances in dietary risk assessment. This opinionidentifies the threshold of toxicological concern (TTC) concept as an appropriate screening tool. TheTTC values for genotoxic and toxic compounds were found to be sufficiently conservative for chronicexposure, as a result of a validation study with a group of pesticides belonging to different chemicalclasses….

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