Zoekresultaten - 50 results
The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.
investigated how HLA-G expression is linked to the patterns of promoter methylation and explored the role of the 3’ UTR polymorphic sites and their binding microRNAs on the post-transcriptional regulation of ...
Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.
Maeyer, Marc; Aertsen, Abram; Noben, Jean-Paul; Luisi, Ben F; Lavigne, Rob Source: Elife, Volume 5 (2016) Keywords: Binding Sites Crystallography, X-Ray Endoribonucleases Host-Parasite Interactions Models, ...
A Tale of Tails: Dissecting the Enhancing Effect of Tailed Primers in Real-Time PCR.
Sequence analysis of the target region of these 5 isolates revealed several mutations in the inter-primer region that extend an existing hairpin structure immediately downstream of the forward primer binding ...
Increased B and T Cell Responses in M. bovis Bacille Calmette-Guerin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen
SLA-1*0801 binding affinity, was promiscuously recognized by 6/6 animals vaccinated with the BCG-pAg85A combination. Our study provides a proof of concept in a large mammalian species, for a new Th1 and CD8 ...
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
Cameron, Craig E; Verdaguer, Nuria; Neyts, Johan; van Kuppeveld, Frank J M Source: PLoS Pathog, Volume 11, Issue 3, p.e1004733 (2015) Keywords: Animals Antiviral Agents Binding Sites Cardiovirus Chlorocebus ...
The immunodominant T-cell epitopes of the mycolyl-transferases of the Antigen 85 complex of M. tuberculosis34076
this protein family. Using synthetic overlapping peptides, bio-informatic prediction programs and tetramer-binding studies, a number of immunodominant CD4 (+) and CD8 (+) T-cell epitopes have been ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
proteases. The assay is based on the induction of expression of a firefly luciferase reporter by a chimeric transcription factor in which the viral protease and cleavage sites are inserted between the GAL4 ...
Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans
displaying intrinsic binding affinity towards streptavidin, was evaluated for the secretory production of two M. tuberculosis immunodominant antigens in Streptomyces lividans and their subsequent downstream ...
The switches.ELM resource: a compendium of conditional regulatory interaction interfaces.
Amino Acid Motifs Amino Acid Sequence Binding Sites Databases, Protein Molecular Sequence Data Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Interaction Maps ...
The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer
esophageal or gastric cancer, respectively. The key molecules attracting leukocytes to local inflammatory sites are chemokines. We here provide a systematic review on the impact of CXC chemokines (binding the ...