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Zoekresultaten - 5 results
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.
had no effect. Disease development was also delayed in mice treated with the MALT1 protease inhibitor mepazine, and in knock-in mice expressing a catalytically inactive MALT1 mutant protein, showing an ...
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.
inactivation of MALT1 in T cells. Finally, treatment of wild-type mice with mepazine, a MALT1 protease inhibitor, also led to mortality upon ERA virus infection. These data emphasize the importance of early ...
HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.
Pol polyprotein) and is a substrate for HIV-1 protease. Incubation in the presence of HIV-1 protease inhibitors resulted in detection of full-length LEDGF /p75 in purified viral particles. We also ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Agents Cell Line Cysteine Endopeptidases Drug Evaluation, Preclinical Genes, Reporter Humans Luciferases, Firefly Picornaviridae Protease Inhibitors Viral Proteins Abstract: Proteolytical cleavage of the ...
Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata.
Th2 mediators was decreased in mice stimulated with the heat-treated extract. Treatment of the extract with protease inhibitors did not affect the induction of the allergic response either, except again ...