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Zoekresultaten - 7 results

Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus.

Gonzalo-Asensio, Jesús Source: Microbiol Spectr (2023) Abstract: A bedaquiline-resistant Mycobacterium abscessus isolate was sequenced, and a candidate mutation in the gene was identified as responsible for the ...

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

for all drugs except ethionamide (91·4%), moxifloxacin (91·6%) and ethambutol (93·3%). Only two resistance mutations were classified for bedaquiline, delamanid, clofazimine, and linezolid as prevalence ...

In vitro activity of bedaquiline against slow-growing nontuberculous mycobacteria.

J Med Microbiol (2019) Keywords: Bedaquiline Mycobacteria nontuberculous Abstract: Bedaquiline (BDQ) is a recently approved antibiotic for the treatment of multidrug-resistant tuberculosis, but its ...

Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

oxygen consumption. The INH-triggered ATP increase and bactericidal activity were strongly compromised by Q203 and bedaquiline, which inhibit mycobacterial cytochrome and FF ATP synthase, respectively. ...

RNA-based drug susceptibility testing of Mycobacterium tuberculosis

v and clinical Mtb strains on ten anti- TB drugs including Bedaquiline, Pyrazinamide and Delamanid was determined, to identify RNA Biomarkers. In a next phase, the RNA-based DST was developed in 96 well ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

linezolid, moxifloxacin and bedaquilin), twice the critical concentration was added to the cultures of two pansensitive M. tuberculosis strains. Samples were taken 0h, 2h, 6h and 24h after the administration ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

multiple samples were combined in one run, reducing time and cost.   Material/methods: For each drug (isoniazid, rifampicin, ethambutol, capreomycin, amikacin, linezolid, moxifloxacin and bedaquilin), twice ...

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