Zoekresultaten - 184 results
Development of a monoclonal antibody sandwich ELISA for the determination of antigen content and quality in diphtheria vaccines.
control of diphtheria vaccines by both manufacturers and national control laboratories relies heavily on in vivo assays to confirm potency. As part of the VAC2VAC project we have developed a monoclonal ...
Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle by.
conclusive data are, however, available concerning the role of subclinically or preclinically infected cattle in virus transmission. Therefore, an in vivo transmission study with 13 donors, experimentally ...
Rational arguments for regulatory acceptance of consistency testing: benefits of non-animal testing over release testing of vaccines.
Issue 1, Number 377 (2023) Abstract: INTRODUCTION: There are rational arguments to replace existing in vivo potency and safety assays for batch release testing of vaccines with more advanced non-animal ...
The Role of EDQM and OMCLs
Publication Type: Scientific poster, presentation or proceeding Authors: Wim Van Molle Source: Responsable des affaires réglementaires, Issue Culture in vivo ASBL (2023) Health Topics: ...
The consistency approach for the substitution of in vivo testing for the quality control of established vaccines: practical considerations and progressive vision
Publication Type: Peer reviewed scientific article Authors: L. Tesolin; J.-F. Dierick; Wim Van Molle Source: Open Research Europe (2022) Keywords: human vaccines in vitro testing in vivo testing ...
Workshop on implementation of single dilution assay for in vivo testing
Publication Type: Scientific poster, presentation or proceeding Authors: F Ribaucour; Morgane Florens; L. Tesolin Source: Workshop on implementation of single dilution assay for in vivo testing, ...
Optimization of Long-Acting Bronchodilator Dose Ratios Using Isolated Guinea Pig Tracheal Rings for Synergistic Combination Therapy in Asthma and COPD.
Volume 15, Issue 8 (2022) Abstract: The co-administration of a long-acting β2-agonist (LABA), and a long-acting muscarinic antagonist (LAMA), has been shown to be beneficial in the management of ...
In Silico Methods for Chromosome Damage.
addressed. For chromosome damage, i.e., the induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data ...
Biological reference standards for multivalent vaccines: qualification strategies and challenges from a national control lab perspective
Publication Type: Scientific poster, presentation or proceeding Authors: L. Tesolin Source: CASS Bioassays 2020, Gaithersburg PA, USA, Sciensano, Gaithersburg, PA, USA (2020) Keywords: in vivo OMCL ...
In silico methods for chromosome damage
induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data without the need for test material, several ...