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ANOVA model for network meta-analysis of diagnostic test accuracy data. [1]

Peer reviewed scientific article

SCIENSANO

Auteurs

Victoria N Nyaga [2]; Aerts, Marc [3]; M. Arbyn [4]

Trefwoorden

    Samenvatting:

    Procedures combining and summarising direct and indirect evidence from independent studies assessing the diagnostic accuracy of different tests for the same disease are referred to network meta-analysis. Network meta-analysis provides a unified inference framework and uses the data more efficiently. Nonetheless, handling the inherent correlation between sensitivity and specificity continues to be a statistical challenge. We developed an arm-based hierarchical model which expresses the logit transformed sensitivity and specificity as the sum of fixed effects for test, correlated study-effect…
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    Samenvatting

    Procedures combining and summarising direct and indirect evidence from independent studies assessing the diagnostic accuracy of different tests for the same disease are referred to network meta-analysis. Network meta-analysis provides a unified inference framework and uses the data more efficiently. Nonetheless, handling the inherent correlation between sensitivity and specificity continues to be a statistical challenge. We developed an arm-based hierarchical model which expresses the logit transformed sensitivity and specificity as the sum of fixed effects for test, correlated study-effects to model the inherent correlation between sensitivity and specificity and a random error associated with various tests evaluated in a given study. We present the accuracy of 11 tests used to triage women with minor cervical lesions to detect cervical precancer. Finally, we compare the results with those from a contrast-based model which expresses the linear predictor as a contrast to a comparator test. The proposed arm-based model is more appealing than the contrast-based model since the former permits more straightforward interpretation of the parameters, makes use of all available data yielding shorter credible intervals, and models more natural variance-covariance matrix structures.

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    Source URL: https://www.sciensano.be/nl/biblio/anova-model-network-meta-analysis-diagnostic-test-accuracy-data

    Links
    [1] https://www.sciensano.be/nl/biblio/anova-model-network-meta-analysis-diagnostic-test-accuracy-data
    [2] https://www.sciensano.be/nl/people/victoria-nyawira-nyaga/biblio
    [3] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=35466&f%5Bsearch%5D=Aerts%2C%20Marc
    [4] https://www.sciensano.be/nl/people/marc-arbyn/biblio