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The effect of enteral tube feeding in cystic fibrosis: A registry based study.

Ziekten en gezondheid in kaart brengen  
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Public Access

Published

Peer reviewed scientific article

Engels

DOI : https://doi.org/10.1016/j.jcf.2018.01.004 [2]

Auteurs

Libeert, Denis [3]; Dimitri, Declercq [4]; Wanyama, Simeon Situma [5]; Thomas, Muriel [6]; Van Daele, Sabine [7]; De Baets, Frans [8]; Van Biervliet, Stephanie [9]

Trefwoorden

  1. Cystic Fibrosis [10]
  2. Gastrostomy [11]
  3. Malnutrition [12]
  4. Pulmonary function [13]
  5. Tube feeding [14]
Article written during project(s) : 
BCFR Belgisch Mucoviscidose Register [15]

Samenvatting:

BACKGROUND: Long-term effect of enteral tube feeding (ETF) in cystic fibrosis (CF) remains equivocal. METHODS: A Belgian CF registry based, retrospective, longitudinal study, evaluated the pre- and post- ETF (n = 113) clinical evolution and compared each patient with 2 age, gender, pancreatic status and genotype class-matched controls. RESULTS: At baseline ETF had a worse BMI z-score (p < 0.0001) and FEV1% (p < 0.0001) compared to controls. Patients eventually receiving ETF, had already a significant worse nutritional status and pulmonary function at first entry in the registry….
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Samenvatting

BACKGROUND: Long-term effect of enteral tube feeding (ETF) in cystic fibrosis (CF) remains equivocal.

METHODS: A Belgian CF registry based, retrospective, longitudinal study, evaluated the pre- and post- ETF (n = 113) clinical evolution and compared each patient with 2 age, gender, pancreatic status and genotype class-matched controls.

RESULTS: At baseline ETF had a worse BMI z-score (p < 0.0001) and FEV1% (p < 0.0001) compared to controls. Patients eventually receiving ETF, had already a significant worse nutritional status and pulmonary function at first entry in the registry. Both parameters displayed a significant decline before ETF-introduction. ETF had more hospitalization and intravenous antibiotic (IVAB) treatment days (p < 0.0001). After ETF introduction hospitalizations and IVAB decreased significantly. After ETF-introduction BMI z-score recuperated towards the original curve before the decline, but remained below the controls. Starting ETF had no effect on rate of height gain in children. The pre-index FEV1 decline (-1.52%/year (p = 0.002)) stabilized to +0.39%/year afterwards. Controls displayed decline of -0.48%/year (p < 0.0001).

CONCLUSION: ETF introduction improved BMI z-score and stabilized FEV1, associated with less hospitalizations and IVAB treatments. Higher mortality and transplantation in the ETF cases, leading to drop-outs, made determination of the effect size difficult.

Associated health topics:

Mucoviscidose [16]
Ziekten en gezondheid in kaart brengen [17]

Source URL: https://www.sciensano.be/nl/biblio/effect-enteral-tube-feeding-cystic-fibrosis-a-registry-based-study

Links
[1] https://www.sciensano.be/sites/default/files/libeert_d_effect_of_enteral_feeding_j_cyst_fibros_2018_1.pdf
[2] https://doi.org/10.1016/j.jcf.2018.01.004
[3] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=86517&amp;f%5Bsearch%5D=Denis%20Libeert
[4] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=86518&amp;f%5Bsearch%5D=Declercq%2C%20Dimitri
[5] https://www.sciensano.be/nl/people/simeon-situma-wanyama/biblio
[6] https://www.sciensano.be/nl/people/muriel-thomas/biblio
[7] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=86520&amp;f%5Bsearch%5D=Sabine%20Van%20Daele
[8] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=86521&amp;f%5Bsearch%5D=Frans%20De%20Baets
[9] https://www.sciensano.be/nl/biblio?f%5Bauthor%5D=86522&amp;f%5Bsearch%5D=Stephanie%20Van%20Biervliet
[10] https://www.sciensano.be/nl/biblio?f%5Bkeyword%5D=18423&amp;f%5Bsearch%5D=Cystic%20Fibrosis
[11] https://www.sciensano.be/nl/biblio?f%5Bkeyword%5D=35773&amp;f%5Bsearch%5D=Gastrostomy
[12] https://www.sciensano.be/nl/biblio?f%5Bkeyword%5D=35774&amp;f%5Bsearch%5D=Malnutrition
[13] https://www.sciensano.be/nl/biblio?f%5Bkeyword%5D=35775&amp;f%5Bsearch%5D=Pulmonary%20function
[14] https://www.sciensano.be/nl/biblio?f%5Bkeyword%5D=35772&amp;f%5Bsearch%5D=Tube%20feeding
[15] https://www.sciensano.be/nl/projecten/belgisch-mucoviscidose-register
[16] https://www.sciensano.be/nl/gezondheidsonderwerpen/mucoviscidose
[17] https://www.sciensano.be/nl/gezondheidsonderwerpen/ziekten-en-gezondheid-kaart-brengen