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Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as ...

Molecular epidemiology and antimicrobial resistance mechanisms of Campylobacter coli from diarrhoeal patients and broiler carcasses in Belgium.

antibiotics (ciprofloxacin, chloramphenicol, nalidixic acid, streptomycin, tetracycline, gentamicin, and erythromycin) were analysed. Strains were most frequently resistant to tetracycline (81.4%), followed by: ...

Application of whole genome data for in silico evaluation of primers and probes routinely employed for the detection of viral species by RT-qPCR using dengue virus as a case study.

targeted nucleic acid regions. Whole genome sequencing allows to characterize and track such changes, which in turn enables to evaluate, optimize, and (re-)design novel and existing RT-qPCR methods. The ...

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

Issue 2, Number 180, p.162-180 (2017) Keywords: a acid Acids Activation an analysi analysis article AS Belgium Brussels Cell Cell Wall cells Class Cytokines disease Diseases electronic Glucose GMM health ...

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.

The 2.2 Å crystal structure reveals that this novel homo-dimeric protein has no identifiable structural homologues. Our biochemical data indicate that acidic patches on the convex outer surface bind RN ...

Prevalence and Diversity of Salmonella Serotypes in Ecuadorian Broilers at Slaughter Age.

florfenicol, kanamycin and nalidixic acid were obtained. Presence of blaCTX-M, blaTEM, blaSHV and blaCMY; and mcr-1 plasmid genes was investigated in resistant strains to cefotaxime and colistin respectively. ...

Evaluation of the Speed-Oligo Mycobacteria assay for the identification of nontuberculous mycobacteria.

Mycobacterium Infections, Nontuberculous Nontuberculous Mycobacteria Nucleic Acid Hybridization Oligonucleotides polymerase chain reaction Reagent Kits, Diagnostic RNA, Ribosomal, 16S Sensitivity and Specificity ...

False-positive rifampicin resistance on Xpert® MTB/RIF caused by a silent mutation in the rpoB gene.

Aged Amikacin Amino Acid Sequence Antibiotics, Antitubercular Bacterial Proteins DNA-Directed RNA Polymerases Drug Resistance, Multiple, Bacterial Ethambutol Ethionamide Fluoroquinolones Genotype Humans ...

Viral interference of the bacterial RNA metabolism machinery.

this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack 2 conserved RNA binding sites on the scaffold ...

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