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Zoekresultaten - 22 results

The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.

investigated how HLA-G expression is linked to the patterns of promoter methylation and explored the role of the 3’ UTR polymorphic sites and their binding microRNAs on the post-transcriptional regulation of ...

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome.

Maeyer, Marc; Aertsen, Abram; Noben, Jean-Paul; Luisi, Ben F; Lavigne, Rob Source: Elife, Volume 5 (2016) Keywords: Binding Sites Crystallography, X-Ray Endoribonucleases Host-Parasite Interactions Models, ...

A Tale of Tails: Dissecting the Enhancing Effect of Tailed Primers in Real-Time PCR.

Sequence analysis of the target region of these 5 isolates revealed several mutations in the inter-primer region that extend an existing hairpin structure immediately downstream of the forward primer binding ...

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

Cameron, Craig E; Verdaguer, Nuria; Neyts, Johan; van Kuppeveld, Frank J M Source: PLoS Pathog, Volume 11, Issue 3, p.e1004733 (2015) Keywords: Animals Antiviral Agents Binding Sites Cardiovirus ...

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

The assay is based on the induction of expression of a firefly luciferase reporter by a chimeric transcription factor in which the viral protease and cleavage sites are inserted between the GAL4 binding ...

The switches.ELM resource: a compendium of conditional regulatory interaction interfaces.

Keywords: Amino Acid Motifs Amino Acid Sequence Binding Sites Databases, Protein Molecular Sequence Data Protein Binding Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Interaction ...

The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer

esophageal or gastric cancer, respectively. The key molecules attracting leukocytes to local inflammatory sites are chemokines. We here provide a systematic review on the impact of CXC chemokines (binding the ...

Antibody evasion by a gammaherpesvirus O-glycan shield.

involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is incomplete. ...

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules36549

Antibodies,Neutralizing Antibody Antibody Specificity Antiviral Agents article Binding Sites Biology biosynthesis Camelids,New World Cross Reactions Dose-Response Relationship,Immunologic electronic Epitopes genetics ...

Identification of a dominant epitope in the hemagglutinin of an Asian highly pathogenic avian influenza H5N1 clade 1 virus by selection of escape mutants.

viruses had Lys (K) at position 189 in the HA1, whereas HA sequences analyzed from dade 2.1 and 2.2 viruses had Arg (R). This residue also interacts with the receptor-binding site, and it is thus important ...

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