Zoekresultaten - 59 results

In silico methods for chromosome damage

Publication Type: Scientific book or chapter Authors: D. Baderna; Ilse Van Overmeire; G.J. Lavado; D. Gadaleta; Birgit Mertens Source: In silico methods for chromosome damage, Volume 2425, Issue ...

Safety assessment of titanium dioxide (E171) as a food additive.

With respect to genotoxicity, the Panel concluded that TiO particles have the potential to induce DNA strand breaks and chromosomal damage, but not gene mutations. No clear correlation was observed ...

CBD oils on the Belgian market: A validated MRM GC-MS/MS method for routine quality control using QuEChERS sample clean up

however, encountered for routine analyses due to the matrix complexity, high cost of cannabinoid standards and low Δ9- THC concentrations. An oily matrix could cause technical damages to analytical ...

Safety assessment of titanium dioxide (E171) as a food additive

foci with E 171, may indicate adverse effects. With respect to genotoxicity, the Panel concluded that TiO2 particles have the potential to induce DNA strand breaks and chromosomal damage, but not gene ...

Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide

modelling. Agglomerate size as a nanodescriptor was well associated with biological endpoints such as DNA damage and/or cytotoxicity. We conclude that, agglomerate size is an important nanodescriptor to assess ...

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

induced gene mutations and chromosome damage in vitro, whereas equivocal results were obtained for the fourth compound. Thus, although there is a legislative framework which excludes the use of CMR ...

New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test

Emilio Source: Toxicology Letters, Volume 329, Number 84 (2020) Keywords: Chromosome damage genotoxicity In silico model In vivo micronucleus QSAR Abstract: A large number of computer-based prediction ...

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

exposed to these suspensions for 24 h and endpoints such as cytotoxicity, total glutathione, epithelial barrier integrity, inflammatory mediators and DNA damage were measured. Large agglomerates of 17 nm ...

Phytochemical screening, antioxidant, anticoagulant and in vitro toxic and genotoxic properties of aerial parts extracts of Fumaria officinalis L. growing in Tunisia

the bacterial Vitotox test. This was confirmed in the comet assay which was conducted on human C3A cells, except for the methanolic extract where DNA damage appeared to be significantly increased at ...

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