Zoekresultaten - 3 results

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.

Due to the exponentially growing number of substances requiring safety evaluation, efficient prioritisation strategies are needed to identify those of highest concern. To limit unnecessary animal ...

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

5 known positive and 5 known negative test compounds for genotoxicity was evaluated. In addition, 2 compounds with debatable genotoxicity data were tested to explore how the qPCR array would classify these. ...

(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.

based on the combination of multiple (quantitative) structure-activity relationship ((Q) SAR) tools. Non-evaluated substances used in printed paper and board food contact materials (FCM) were selected for ...

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