Zoekresultaten - 17 results

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...

P20-10: Microcystin-LR and aflatoxin M1 contamination in dairy milk samples and their combined in vitro hepatotoxicity

Publication Type: Peer reviewed scientific article Authors: Mohamed F. Abdallah; Van Camp, C.; Recote, J. May; Wannes Van Hassel *; Julien Masquelier *; A. Rajkovic Source: Toxicology Letters, ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells

shift towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Service:  Évaluation des risques et de l'impact sur la santé Risico- en ...

In Silico Methods for Chromosome Damage.

addressed. For chromosome damage, i.e., the induction of structural or numerical chromosome aberrations, several in vitro and in vivo test methods are available. In order to rapidly collect toxicological data ...

Brussels region finances VUB research into alternatives to animal experiments

That part of the grant amounts to €50,000. Along those lines, VUB researchers are currently investigating the possibility of using in-vitro models for toxicological research, which would not use living ...

Assessment of hazards and risks associated with dietary exposure to mineral oil for the Belgian population

used as point of departure (PoD). Due to existing toxicological uncertainties, the margin of exposure (MOE) approach was applied. In all investigated scenarios, the MOE values were well above 100, ...

Identifying nanodescriptors to predict the toxicity of nanomaterials: a case study on titanium dioxide

the toxicological effects of TiO2  NM s in vitro. However, the agglomeration state of NM s can be potentially influenced by in vitro exposure conditions and such influences could be just a confounder in ...

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

transhexanal, there was a clear concern for in vivo genotoxicity. A selection of 4 out of the remaining 22 flavourings was tested in two in vitro genotoxicity assays. Three out of the four tested flavourings ...

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

A toxicologically relevant definition of NM s is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the ...

Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative DiphenpipenolAbstract

Christophe Source: Journal of Analytical Toxicology (2020) Service:  Médicaments et produits de santé Geneesmiddelen en gezondheidsproducten Medicines and health products Manuscript versions:  DOI:  ...

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