Zoekresultaten - 14 results

A roadmap for regulatory implementation of in vitro models for evaluation of vaccine efficacy

Publication Type: Scientific poster, presentation or proceeding Authors: R. J. Vandebriel; L. Tesolin; K. Veenstra; K. Huber Source: EVI, Niagara falls, Canada (2023) Keywords: in vitro model ...

Homologous versus heterologous prime-boost COVID-19 vaccination: impact on clinical severity of Omicron among hospitalized COVID-19 patients in Belgium

the study population. An adjusted logistic model was build and g-computation was executed to estimate counterfactual risks of different clinical severity outcomes (intensive care unit (ICU) transfer, ...

Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact

Publication Type: Peer reviewed scientific article Authors: Jungbluth, Stefan; Martin, William; Slezak, Monika; Depraetere, Hilde; Guzman, Carlos A.; Ussi, Anton; Morrow, David; Van Heuverswyn, Fran; Arnouts, Sven; Carrondo, Manuel J. T.; Olesen, Ole; Ott ...

Vaccine effectiveness against onward transmission of SARS-CoV2-infection by variant of concern and time since vaccination, Belgian contact tracing, 2021.

infectiousness of breakthrough cases (VE i) for a complete schedule of Ad26. COV2.S, ChAdOx1, BNT162 b2, mRNA-1273 as well as infection-acquired and hybrid immunity. We used a multilevel Bayesian model and ...

Incidence and Risk Factors of COVID-19 Vaccine Breakthrough Infections: A Prospective Cohort Study in Belgium.

associated with breakthrough infections were analyzed using COX proportional hazard models. Among 8,062,600 fully vaccinated adults, we identified 373,070 breakthrough infections with an incidence of 11.2 (95% ...

Chemical and toxciological characterization of e-liquid cigarettes

quantitative in silico models. In total, potential genotoxicity activity was predicted for 44 flavourings. Based on information from European databases, genotoxicity could be confirmed for five of these ...

Human challenge trial workshop: Focus on quality requirements for challenge agents, Langen, Germany, October 22, 2019.

Keywords: Biological Products Drug Development Human Experimentation Humans vaccines whole genome sequencing Abstract: Controlled human infection models can be helpful to study pathogenesis and immune ...

Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills

investigated in silico with two complementary (quantitative) structure-activity relationship ((Q) SAR) models (Derek Nexus, Sarah Nexus). In total, 57 flavouring components were identified with a structural ...

A new approach to define acceptance limits for hematology in external quality assessment schemes.

their corresponding assigned value (U-scores) was modeled by means of an adaptation of Thompson’s “characteristic function”. Quantile regression was used to investigate the percentiles of the U-scores for ...

Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines.

Adjuvants, Immunologic Animals Antigens, Bacterial Cell Wall Humans Immunity, Innate Lectins, C-Type Models, Animal Mycobacterium Pathogen-Associated Molecular Pattern Molecules Protein Binding Signal ...

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