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Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation.

and enhanced oxygen consumption. The INH-triggered ATP increase and bactericidal activity were strongly compromised by Q203 and bedaquiline, which inhibit mycobacterial cytochrome and FF ATP synthase, ...

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

Hypothesis Immunisation immunology Infectious Infectious diseases Institute IS journal mechanism mice MODEL Mycobacterium Mycobacterium tuberculosis Mycolic Acids ON Oxygen pathogenic production public public ...

Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts

detoxification of reactive oxygen species produced during mutagenesis. Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Risques chimiques et physiques pour la santé ...

The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high antioxidant activity.

and DNA damage by reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been identified in numerous human syndromes. Oxidative DNA damage plays a significant role in mutagenesis, ...

Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

single synthetic MA s, differing in oxygenation class and cis versus trans proximal cyclopropane configuration, as immune stimulatory agents. Subcutaneous delivery of liposome-formulated MA s with ...

Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro.

Heat-Shock Proteins Humans Metal Nanoparticles Oxidative Stress p38 Mitogen-Activated Protein Kinases Pulmonary Alveoli Reactive Oxygen Species Titanium Abstract: The health risks of nanoparticles remain ...

Biochemical analysis of the NAD+-dependent malate dehydrogenase, a substrate of several serine/threonine protein kinases of Mycobacterium tuberculosis

Immunoprecipitation analysis revealed that MDH was hyperphosphorylated in the bacteria at the beginning of the stationary and under oxygen-limited conditions by STPK s other than PknD. On the contrary, when ...

Foodborne cereulide causes beta-cell dysfunction and apoptosis.

homologous protein). Mitochondria appeared swollen upon transmission electron microscopy, basal respiration rate was reduced by 52% (P <0.05) and reactive oxygen species increased by more than twofold (P ...

Towards a typing strategy for Arcobacter species isolated from humans and animals and assessment of the in vitro genomic stability.

assessed under two temperatures and two oxygen concentrations. Variability in the genomic profile of A. cryaerophilus was observed after different passages for different strains at 37°C under microaerobic ...

M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.

Mutation Mycobacterium bovis Mycobacterium tuberculosis Mycolic Acids Organ Specificity Oxygen Species Specificity Spleen Th1 Cells Th17 Cells Trachea Treatment Outcome Tuberculosis Vaccination virulence ...

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