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An update on vaccines for tuberculosis- there is more to it than just waning of BCG efficacy with time.

of MHC class I restricted responses. Prime-boost strategies based on the actual BCG vaccine may not be sufficient to overcome this hurdle. The use of plasmid DNA vaccination might offer a solution. ...

Immunogenicity of eight Mycobacterium avium subsp. paratuberculosis specific antigens in DNA vaccinated and Map infected mice.

Ag5, Ag6, MAP1637 c, MAP0388 and MAP3743 (identified by bioinformatic in silico screening of the Map genome). Strong, antigen-specific IFN-γ responses were induced in mice vaccinated with plasmid DNA ...

Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines.

that Rv1009 (rpfB) and Rv2389c (rpfD) are the most antigenic in the tested models. We therefore selected rpfB and rpfD for testing their vaccine potential as plasmid DNA vaccines. Elevated cellular ...

Buruli ulcer

about disease transmission and there is no vaccine. There have been several recent advances in the field. These include sequencing of the bacterial genome and of the giant plasmid responsible for ...

Application of the Modular Approach to an In-House Validation Study of Real-Time PCR Methods for the Detection and Serogroup Determination of Verocytotoxigenic Escherichia coli4844

Laboratories Limit of Detection method methods microbiology modular Molecular Molecular biology Monitoring ON outbreak outbreaks parameters PCR performance Plasmids PROCESSES protection RANGE real time PCR ...

Overlapping signals for translational regulation and packaging of influenza A virus segment 2.

mutated AUG s 1-4 and monitored polypeptide synthesis from plasmids and recombinant viruses. This identified sORF2 as a key regulatory element with opposing effects on PB1- F2 and PB1- N40 expression. We ...

Capsid proteins from field strains of foot-and-mouth disease virus confer a pathogenic phenotype in cattle on an attenuated, cell-culture-adapted virus

Volume 92, Issue 5, Number 1151 (2011) Abstract: Chimeric foot-and-mouth disease viruses (FMDV s) have been generated from plasmids containing full-length FMDV cDNAs and characterized. The parental virus ...

Antifungal activity displayed by cereulide, the emetic toxin produced by Bacillus cereus

food Fungi Gene Deletion Genes,Bacterial growth & development im IS journal Laboratories metabolism Microbial Sensitivity Tests microbiology pharmacology Plasmids Research Research Support Role SB- ...

Intranasal DNA vaccination induces potent mucosal and systemic immune responses and cross-protective immunity against influenza viruses.

pathogenic H5N1 strain that could be improved by adding neuraminidase (NA) DNA plasmids. Our observations warrant further investigation of intranasal DNA as an effective vaccination route. Health Topics:  ...

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