Zoekresultaten - 7 results

The 2021 WHO catalogue of complex mutations associated with drug resistance: A genotypic analysis.

resistance, or consistent with susceptibility, for 13 WHO endorsed anti-tuberculosis drugs. 38,215 MTBC isolates with paired whole-genome sequencing and phenotypic drug susceptibility testing data were amassed ...

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

Organization priority. We previously developed a software tool,, which provided offline species identification and drug resistance predictions for from whole genome sequencing (WGS) data. Performance was ...

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.

profiles; phenotypic resistance to isoniazid, rifampicin, ethambutol, pyrazinamide, and capreomycin; and corresponding drug resistance mutations. We whole-genome sequenced all Mycobacterium tuberculosis ...

Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection

Abstract: Mycobacterium avium subsp. hominissuis (Mah) represents a health concern for humans and to a lesser extent for pigs, but its zoonotic potential remains elusive. Using multispacer sequence typing ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

Moreover, comparing the response of sensitive and resistant strains can yield additional information, like the activation of specific efflux pumps. However, due to the high cost of RNA seq analyses, genome ...

Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs

sensitive and resistant strains can yield additional information, like the activation of specific efflux pumps. However, due to the high cost of RNA seq analyses, genome wide transcriptional analyses of drug ...

Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid

a pressure of the recently approved delamanid is investigated. Total RNA sequencing revealed that the response to this bicyclic nitroimidazole shows many similarities with pretomanid, an anti-tuberculous drug ...

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