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Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis.

we determined the immunodominant Th1-type CD4 (+) T cell epitopes in C57BL /10 mice, as measured by spleen cell IL-2 and IFN-gamma production. Furthermore, a potent IFN-gamma-inducing, D(b)-restricted ...

Monitoring of pigeon paramyxovirus type-1 in organs of pigeons naturally infected with Salmonella Typhimurium.

observed. The spread of pPMV-1 was relatively quick, all organs being largely positive at 4 days after inoculation or contact. The lung, spleen, caecal tonsils, kidneys and brain, for which almost all tested ...

Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis.

Ag85B, and Ag85C from M. tuberculosis. Th1-type spleen cell cytokine secretion of interleukin-2 (IL-2) and gamma interferon (IFN-gamma) was analyzed in response to purified Ag85 components and synthetic ...

Improved tuberculosis DNA vaccines by formulation in cationic lipids.

Phosphatidylethanolamines Spleen T-Lymphocytes, Cytotoxic Th1 Cells Tuberculosis Vaccination Vaccines, DNA Abstract: Mice were vaccinated with plasmid DNA (pDNA) encoding antigen 85A (Ag85A), Ag85B, or PstS-3 from ...

Dynamics of immune cell infiltration in the caecal lamina propria of chickens after neonatal infection with a Salmonella enteritidis strain.

Infections, Animal Spleen T-Lymphocytes Abstract: Dynamics of leucocyte infiltration and bacterial invasion in the caecal wall were studied after oral infection of 2-day-old chicks with Salmonella enterica ser. ...

Morbillivirus in common seals stranded on the coasts of Belgium and northern France during summer 1998.

was observed in a few lymphocytes in the spleen and lymph nodes of three seals. Anti- CDV neutralising antibodies were detected in sera from six animals. Seven of the seals were positive by reverse ...

Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting.

interferon (IFN-gamma) response in spleen two- to fourfold. Further, intracellular cytokine analysis by flow cytometry also showed an increase in IFN-gamma-producing CD4 (+) T cells in ...

CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A.

cytokines similar to wild-type mice. Although beta2m-/- mice were more susceptible to M. tuberculosis infection, following vaccination they efficiently controlled bacterial replication in spleen and lungs ...

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