Zoekresultaten - 69 results

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.

efficiently identify pollutants of interest. The evidence will be integrated in novel Adverse Outcome Pathways to facilitate regulatory acceptance of non-animal methods for cardiotoxicity testing. The current ...

An AOP-based IATA to pave the way toward animal-free genotoxicity testing

Integrated approaches to testing and assessment (IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé ...

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake

Birgit Mertens Source: 57th Congress of the European Societies of Toxicology, Ljubljana, Slovenia (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment ...

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake

Birgit Mertens Source: Joint 3R Symposium, Brussels, Belgium (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment (IATA) pollutants Health Topics:  ...

Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity Assessment

testing and assessment (IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé Risico- en ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  ...

Development of an AOP-based IATA for genotoxicity

Integrated approaches to testing and assessment (IATA) Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  Évaluation des risques et de l'impact sur la santé ...

Development of strain-level shotgun metagenomics approaches to detect and characterize microbiological contaminants in the context of food safety

It was proven that whole genome sequencing has a higher resolution than any combination of tests carried out so far. But the isolation is not always possible, and it is time-consuming. A new method ...

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