Zoekresultaten - 69 results
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.
efficiently identify pollutants of interest. The evidence will be integrated in novel Adverse Outcome Pathways to facilitate regulatory acceptance of non-animal methods for cardiotoxicity testing. The current ...
EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects
submitted to a thorough physicochemical characterisation. A battery of in vitro tests was used to provide insight into NC hazard and mode of action according to a tiered approach, which lead to selection of ...
An AOP-based IATA to pave the way toward animal-free genotoxicity testing
Integrated approaches to testing and assessment (IATA) Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation des risques et de l'impact sur la santé ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Birgit Mertens Source: 57th Congress of the European Societies of Toxicology, Ljubljana, Slovenia (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Birgit Mertens Source: Joint 3R Symposium, Brussels, Belgium (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment (IATA) pollutants Health Topics: ...
Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity Assessment
testing and assessment (IATA) Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation des risques et de l'impact sur la santé Risico- en ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: ...
Development of an AOP-based IATA for genotoxicity
Integrated approaches to testing and assessment (IATA) Health Topics: Health and environment Santé et environnement Gezondheid en milieu Service: Évaluation des risques et de l'impact sur la santé ...
Development of strain-level shotgun metagenomics approaches to detect and characterize microbiological contaminants in the context of food safety
It was proven that whole genome sequencing has a higher resolution than any combination of tests carried out so far. But the isolation is not always possible, and it is time-consuming. A new method ...
Comparison of 6 DNA extraction methods for isolation of high yield of high molecular weight DNA suitable for shotgun metagenomics Nanopore sequencing to detect bacteriaAbstractBackgroundResultsConclusion
on-site application. In addition to the comparison of the quality, quantity and purity of the extracted DNA, the performance obtained when doing Nanopore sequencing on a MinION flow cell was also tested ...