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Zoekresultaten - 12 results
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
Issue 2 (2023) Keywords: Algorithms Animals Biomarkers DNA Damage Gene Expression Profiling Humans Supervised Machine Learning Abstract: Transcriptomics-based biomarkers are promising new approach ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells
genetic toxicology GENOMARK biomarker predictive toxicology human health risk assessment new approach methodologies (NAMs) Abstract: Transcriptomics-based biomarkers are promising new approach methodologies ...
Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19.
different stages of the disease. In patients with acute severe COVID-19, we identified a specific transcriptomic and epigenomic state in monocytes that can account for their functional refractoriness. The ...
Preparing cDNA Libraries from Lytic Phage-Infected Cells for Whole Transcriptome Analysis by RNA-Seq.
Publication Type: Peer reviewed scientific article Authors: Blasdel, Bob; Pieter-Jan Ceyssens; Lavigne, Rob Source: Methods Mol Biol, Volume 1681, Issue 1681, Number 1941 (2018) Keywords: Bacteriophage RNA-seq Abstract: Whole genome wide analysis of trans ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
approaches, we have developed an upgraded, innovative, and proprietary gene classifier. This gene classifier is based on transcriptomic changes induced by 12 genotoxic and 12 non-genotoxic reference compounds ...
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Transcriptome Workflow Abstract: The assessment of the carcinogenic potential of chemicals with alternative, human-based in vitro systems has become a major goal of toxicogenomics. The central read-out of these ...
In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.
Alessandra; Milushev, Dimiter; Benfenati, Emilio; Rogiers, Vera; Doktorova, Tatyana Y Source: Mutagenesis, Volume 31, Number 461, p.453-61 (2016) Keywords: Cosmetics In silico Mutagenicity Tests Transcriptomics ...
FabR regulates Salmonella biofilm formation via its direct target FabB.
applied a combinatorial high-throughput approach, combining ChIP-chip with transcriptomics. RESULTS: All the previously identified E. coli FabR transcriptional target genes (fabA, fabB and yqfA) were shown ...
Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and management of infectious diseases?
of genomic, transcriptomic, and proteomic data. A clear example of this step-change is represented by the amount of DNA sequence data that can be now produced using next-generation sequencing (NGS) ...
Modulation of early beta-defensin-2 production as a mechanism developed by type I Toxoplasma gondii to evade human intestinal immunity36564
strains. Transcriptome analysis revealed that among differentially expressed genes, beta-defensins distinguished the most IEC infected by fast- or slow-replicating T. gondii genotypes. Although beta-defensin ...