Zoekresultaten - 37 results

Identification of flavouring substances of genotoxic concern present in e-cigarette refills

E-cigarettes have become very popular, a trend that has been stimulated by the wide variety of available e-liquid flavours. Considering the large number of e-liquid flavours (>7000), there is an urgent need ...

Identification of Flavouring Substances of Genotoxic Concern Present in E-Cigarette Refills

increased significantly. An important contributor to this trend is the availability of a wide variety of flavours used in e-liquid refills. However, the role of these flavouring components in the potential ...

Chemometrics and chromatographic fingerprints to classify plant food supplements according to the content of regulated plants.

supplements are gaining popularity, resulting in a broader spectrum of available products and an increased consumption. Next to the problem of adulteration of these products with synthetic drugs the presence of ...

Detection of regulated herbs and plants in plant food supplements and traditional medicines using infrared spectroscopy.

IR data, using SIMCA as modelling technique. During validation of the model, using an external test set, 21 of 25 were correctly classified and six of the nine targeted plants showed no ...

Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future.

showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer ≥80-year-old subjects with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of ...

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).

issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the ...

Commentary on the MID3 Good Practices Paper.

in promoting greater consistency in practice, application, and documentation of M&S and considers the paper is an important contribution towards achieving this objective. Health Topics:  ...

The ADVANCE Code of Conduct for collaborative vaccine studies.

Collaboration in Europe (ADVANCE) consortium was established to create an efficient and sustainable infrastructure for rapid and integrated monitoring of post-approval benefit-risk of vaccines, including a code ...

Chromatographic fingerprinting as a strategy to identify regulated plants in illegal herbal supplements.

Tribulus terrestris. The full factorial design demonstrated that for all three plant references a C8 column (250mm×4.6mm; 5µm particle size) is best suited; methanol and an ammonium formate buffer (pH 3) ...

The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.

vivo human embryogenesis. Human embryonic stem cells (hESC) provide an interesting in vitro model to study early human development. Different studies reported discrepant findings on whether HLA-G mRNA ...

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