Zoekresultaten - 76 results

Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future.

with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD ...

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).

issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the ...

Commentary on the MID3 Good Practices Paper.

Model-Informed Drug Discovery and Development (MID3) group in promoting greater consistency in practice, application, and documentation of M&S and considers the paper is an important contribution towards ...

Characterization of suspected dermal fillers containing hyaluronic acid

validation of a specific identification and quantification method is described. The proposed method utilizes an essential pre-extraction step prior to identification by infra-red spectroscopy followed by an ...

The ADVANCE Code of Conduct for collaborative vaccine studies.

benefit-risk Collaboration in Europe (ADVANCE) consortium was established to create an efficient and sustainable infrastructure for rapid and integrated monitoring of post-approval benefit-risk of vaccines, ...

Chromatographic fingerprinting as a strategy to identify regulated plants in illegal herbal supplements.

Tribulus terrestris. The full factorial design demonstrated that for all three plant references a C8 column (250mm×4.6mm; 5µm particle size) is best suited; methanol and an ammonium formate buffer (pH 3) ...

The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells.

vivo human embryogenesis. Human embryonic stem cells (hESC) provide an interesting in vitro model to study early human development. Different studies reported discrepant findings on whether HLA-G mRNA ...

An application of mass spectrometry for quality control of biologicals: Highly sensitive profiling of plasma residuals in human plasma-derived immunoglobulin.

at 1ng/mg in Ig, which is below the minimal thrombotic dose of 3ng/mg observed in an in vivo model. Relative label-free quantitation highlighted significant differences in normalized abundances of ...

The fate of buccal bone around dental implants. A 12-month postloading follow-up study.

28, Issue 1, p.103-108 (2017) Abstract: INTRODUCTION AND AIM: Buccal bone thickness is considered to be an important factor during implant surgery. Its resorption might have an effect on the soft tissue ...

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

different laboratories, are still uncommon. Furthermore, there is limited knowledge about variability induced by the data analysis protocols. We have conducted an inter-laboratory study for testing chemical ...

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