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Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production

Publication Type: Peer reviewed scientific article Authors: Antoine Francotte; Raphael Esson; Eric Abachin; Melissa Vanhamme; Alexandre Dobly; Bruce Carpick; Sylvie Uhlrich; Jean-François Dierick; Celine Vanhee Source: Talanta, Volume 236 (2022) Health To ...

Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production

present in the cell culture medium of two TeNT production batches during different steps in the vaccine production process prior to the generation of the toxoid. The amount of TeNT generated under different ...

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