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Zoekresultaten - 7 results
Guidance in selecting analytical techniques for identification and quantification of non-intentionally added substances (NIAS) in food contact materials (FCMS)
different results and it can be difficult to make meaningful comparisons. The initial approach was to attempt to prepare a prescriptive methodology but as this proved impossible; this paper develops ...
Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials.
testing, such strategies should respect the 3R principles (Replacement, Reduction, Refinement). In the present study, a strategy based on non-animal approaches was developed to prioritize non-evaluated ...
A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
regulatory accepted batteries for in vitro genotoxicity testing is recognized, they result in a high number of false positives. This has a major impact on society and industries developing novel compounds ...
Coatings in food contact materials: Potential source of genotoxic contaminants?
use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for ...
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances.
methods such as in silico (i.e. computational) techniques gain more and more importance. In the current study, a new prioritization strategy for identifying potentially mutagenic substances was developed ...
Study of the possible migration risks of food contact materials for children under 3 years
simulant with a mixture of common organic compounds (Chapter 4.1) was optimised. To develop a robust and general method, a mixture of 17 chemicals (identified in the literature as possible migrants from FCM ...
Development and application of a non-target extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS.
Accepted (2015) Keywords: alternatives analysis Antioxidant Antioxidants application AS Babies baby bottle Baby bottles Bisphenol-A chemicals comparing CONTACT Context Development differences food food ...