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Zoekresultaten - 75 results
In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.
have been developed to test for genotoxicity. In a first tier, a battery of two to three in vitro tests is recommended to cover mutagenicity, clastogenicity and aneugenicity as main endpoints. This ...
Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro.
microvascular cells were sensitive to endogenous redox changes and underwent apoptosis, but not alveolar epithelial A549 cells. Genotoxic potential of titanium dioxide nanoparticles was investigated using the ...
Scientific Opinion on the Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food
treatment with glycidol increased the incidence of tumours in several tissues of rats and mice, likely via a genotoxic mode of action. The Panel selected aBMDL10 value for 3- MCPD of 0.077 mg/kg bw per day ...
Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability.
assessor’s reasoning to omit a MoS calculation and to focus more on local toxicity and mutagenicity/genotoxicity for ingredients for which limited systemic exposure is to be expected. Health Topics: ...
Investigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern.
polycarbonate (PC) have been introduced on the European market. However, PC-replacement products might also release substances of which the toxicological profile–including their genotoxic effects–has not yet been ...
Evaluation of the genotoxicity and cytotoxicity of semipurified fractions from the Mediterranean brown algae, Dictyopteris membranacea
4, Number S399 (2016) Keywords: cytotoxicity Dictyopteris membranacea genotoxicity micronucleus Test Vitotox test Service: Risques chimiques et physiques pour la santé Chemische en fysische ...
Co-exposure of ELF-magnetic fields and chemical mutagens: An investigation of genotoxicity with the SOS-based VITOTOX test in Salmonella typhimurium.
Publication Type: Peer reviewed scientific article Authors: Luc Verschaeve; Wambacq, Sheleen; Anthonissen, Roel; Annemarie Maes Source: Mutat Res Genet Toxicol Environ Mutagen, Volume 795, Number 35, p.31-5 (2016) Keywords: DNA Damage DNA, Bacterial Dose- ...
Genotoxicity and Antigenotoxicity Studies of Traditional Medicinal Plants: How Informative and Accurate are the Results?
Mutagens Phytotherapy Plant Extracts Plants, Medicinal Abstract: Genotoxicity and antigenotoxicity studies of (traditional medicinal) plants are important from a risk assessment point of view and in the ...
Phytochemical Composition and Potential Genotoxic effects of Important Egyptian Medicinal Plants
Publication Type: Peer reviewed scientific article Authors: Rashed, Khaled; R. Anthonissen; D. Cappoen; Luc Verschaeve Source: Pharmacognosy Communications, Volume 5, Issue 3, Number 216 (2015) Keywords: Alkaline comet assay Egyptian medicinal plants Meth ...
Pyrrolizidine alkaloids in food and feed on the Belgian market.
distributed plant toxins with species dependent hepatotoxic, carcinogenic, genotoxic and pneumotoxic risks. In a recent European Food Safety Authority (EFSA) opinion, only two data sets from one European ...