Zoekresultaten - 105 results

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial.

Count Coinfection Double-Blind Method Female Healthy Volunteers HIV Infections Hiv-1 Humans Immunity, Active Immunization, Secondary Immunoglobulin G Injections, Intradermal Male middle aged Mycobacterium ...

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

Nucleoside-based inhibitors have broad-spectrum activity but often exhibit off-target effects. Most non-nucleoside inhibitors (NNI s) target surface cavities, which are structurally more flexible than the ...

A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus.

replication cycle experiment’ without losing its antiviral activity. The genetic characterization of progressively selected resistant FMD viruses shows that the molecule presumably interacts with the ...

Development of giant bacteriophage phiKZ is independent of the host transcription apparatus

Journal of Virology, Volume 88, Issue 18, Number 10510, p.10501- 10510 (2014) Keywords: 0 Absence Activity article Bacterial Proteins Bacteriophages Belgium Beta Biology Cell data Development DNA-Directed ...

In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.

Viral Drug Discovery Foot-and-Mouth Disease Models, Theoretical Oximes Ribavirin RNA, Viral Sulfonamides Virus Cultivation Virus Replication Abstract: Foot-and-mouth disease virus (FMDV) is a highly ...

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

compounds on protease activity in cells while circumventing the need for infection. We designed the assay for 3C proteases (3C(pro)) of various enteroviruses as well as of viruses of several other ...

Serological evidence of Ostertagia ostertagi infection in dairy cows does not impact the efficacy of rabies vaccination during the housing period33969

serum antibody levels against O. ostertagi on day 0 were compared with anti-rabies IgM, IgA, IgG1, IgG2 and virus-neutralizing antibodies on days 0, 7, 14 and 21 after vaccination. In addition, to explore ...

Infectious Bursal Disease: a complex host-pathogen interaction.

virus Macrophage Activation Macrophages T-Lymphocytes Viral Vaccines Abstract: Infectious Bursal Disease (IBD) is caused by a small, non-enveloped virus, highly resistant in the outside environment. ...

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