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Nicolas Bruffaerts, Christelle Vluggen, Virginie Roupie, Lucille Duytschaever, Christophe Van den Poel, Joseph Denoël, Ruddy Wattiez, Jean-Jacques Letesson, David Fretin, Leen Rigouts, Ophélie Chapeira, Vanessa Mathys, Claude Saegerman, Kris Huygen
Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection
www.plosone.org
www.plosone.org
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(15)Tj
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(].)Tj
2.0806 0 Td
(MST)Tj
/F15 1 Tf
(12)Tj
/F9 1 Tf
-33.5733 -1.2983 Td
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1.7291 0 Td
(MST)Tj
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(22)Tj
/F9 1 Tf
3.1918 0 Td
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4.2179 0 Td
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2.126 0 Td
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2.0579 0 Td
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(in)Tj
1.0318 0 Td
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2.058 0 Td
(whereas)Tj
3.4469 0 Td
(MST)Tj
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(15)Tj
/F9 1 Tf
(,)Tj
3.4185 0 Td
(the)Tj
-36.0507 -1.2983 Td
(second)Tj
3.0103 0 Td
(most)Tj
2.2054 0 Td
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3.7984 0 Td
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-32.4451 -1.3039 Td
[()8()]TJ
0.907 0 Td
[()11()]TJ
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(12/67)Tj
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/F15 1 Tf
(13)Tj
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3.1917 0 Td
(whereas)Tj
3.447 0 Td
(in)Tj
1.0318 0 Td
(our)Tj
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(only)Tj
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(13)Tj
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(].)Tj
2.0806 0 Td
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(contrast,)Tj
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(only)Tj
1.9729 0 Td
(1/67)Tj
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(isolates)Tj
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1.7064 0 Td
(the)Tj
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(22)Tj
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(pulmonary)Tj
4.6431 0 Td
(disease\))Tj
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(whereas)Tj
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(22)Tj
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3.1917 0 Td
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(5/92)Tj
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(7/54)Tj
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(porcine)Tj
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(isolates\).)Tj
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(12)Tj
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(human)Tj
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(and)Tj
1.7292 0 Td
(28/54)Tj
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(porcine)Tj
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(isolates\).)Tj
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(determine)Tj
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(evolution)Tj
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(of)Tj
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[()]TJ
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(.)Tj
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1.3209 0 Td
[()22(\r)-13(\n)12()12()]TJ
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2.7099 0 Td
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(panels)Tj
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(isolates)Tj
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(19671968)Tj
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(and)Tj
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(1992)Tj
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(1996\).)Tj
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[()28()11()]TJ
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(reported)Tj
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2.999 0 Td
(the)Tj
1.4684 0 Td
(20122013)Tj
4.541 0 Td
(isolates,)Tj
3.3449 0 Td
(a)Tj
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(significant)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 409.096 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Virulence)Tj
4.3086 0 Td
(and)Tj
1.8568 0 Td
(genetic)Tj
3.3874 0 Td
(diversity)Tj
3.8197 0 Td
(of)Tj
/F8 1 Tf
1.0347 0 Td
(M)Tj
/F0 1 Tf
(.)Tj
/F8 1 Tf
1.3252 0 Td
(hominissuis)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
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(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0171)Tj
3.5434 0 Td
(895)Tj
2.6362 0 Td
(February)Tj
4.1599 0 Td
(9,)Tj
1.0417 0 Td
(2017)Tj
37.8995 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(19)Tj
/F11 1 Tf
-0.025 Tc
-66.402 84.0904 Td
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4.3228 0 Td
(s)Tj
0.6449 0 Td
(&)Tj
0.8575 0 Td
(Mycobacte)Tj
4.0607 0 Td
(ria)Tj
1.148 0 Td
(is)Tj
0.8291 0 Td
(partially)Tj
3.104 0 Td
(supporte)Tj
3.2953 0 Td
(d)Tj
-18.2623 -1.3748 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3748 0 Td
(Belgian)Tj
2.9197 0 Td
(Ministry)Tj
3.2386 0 Td
(of)Tj
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(through)Tj
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(a)Tj
-17.7875 -1.3749 Td
(fund)Tj
1.8921 0 Td
(within)Tj
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(the)Tj
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-15.4205 -1.3748 Td
(funders)Tj
3.0472 0 Td
(played)Tj
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(no)Tj
1.1693 0 Td
(role)Tj
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(in)Tj
0.8859 0 Td
(the)Tj
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(study)Tj
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(design,)Tj
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(data)Tj
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(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(analysis)Tj
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(,)Tj
0.4464 0 Td
(decision)Tj
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(to)Tj
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(publish,)Tj
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(or)Tj
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(preparation)Tj
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(of)Tj
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(manuscript.)Tj
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0.8859 0 Td
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(salaries)Tj
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(for)Tj
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(author)Tj
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(but)Tj
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(any)Tj
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(the)Tj
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(data)Tj
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(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
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(publish,)Tj
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(or)Tj
0.9993 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
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4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
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()Tj
-0.025 Tc
0.3615 -0.0284 Td
(lie)Tj
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(ra)Tj
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(employed)Tj
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(by)Tj
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(n.)Tj
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(are)Tj
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(no)Tj
1.1693 0 Td
(patents,)Tj
-14.6906 -1.3748 Td
(products)Tj
3.522 0 Td
(in)Tj
0.8859 0 Td
(developm)Tj
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(ent)Tj
1.3678 0 Td
(or)Tj
1.0063 0 Td
(markete)Tj
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1 J
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(10%)Tj
1.9332 0 Td
(OADC.)Tj
-33.2897 -1.2982 Td
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2.2847 0 Td
(blood)Tj
2.5115 0 Td
(sampling,)Tj
4.1045 0 Td
(animals)Tj
3.3335 0 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.8051 0 Td
(5/group)Tj
3.4129 0 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0238 0 Td
(time)Tj
2.0296 0 Td
(point\))Tj
2.6986 0 Td
(were)Tj
2.1259 0 Td
(sacrificed)Tj
4.0025 0 Td
(by)Tj
1.1849 0 Td
(cervical)Tj
3.2655 0 Td
(dis-)Tj
-35.8409 -1.2983 Td
(location.)Tj
3.6737 0 Td
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2.0239 0 Td
(infection)Tj
3.7927 0 Td
(runs)Tj
2.0296 0 Td
(were)Tj
2.1203 0 Td
(realized,)Tj
3.5546 0 Td
(one)Tj
1.6951 0 Td
(run)Tj
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(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(eight)Tj
2.1997 0 Td
(isolates)Tj
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(and)Tj
1.7292 0 Td
(mice)Tj
2.1543 0 Td
(sacrificed)Tj
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(week)Tj
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(1,)Tj
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(5,)Tj
0.9184 0 Td
(10)Tj
1.1736 0 Td
(and)Tj
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(20)Tj
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(weeks)Tj
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(post-infection)Tj
5.8223 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6577 0 Td
(second)Tj
3.0103 0 Td
(run)Tj
1.6667 0 Td
(with)Tj
1.9956 0 Td
(seven)Tj
2.4321 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(eight)Tj
2.2054 0 Td
(isolates)Tj
-33.7263 -1.3039 Td
(\(Hu)Tj
/F15 1 Tf
(15)Tj
/F9 1 Tf
2.8459 0 Td
(isolate)Tj
2.7553 0 Td
(missing\),)Tj
3.8778 0 Td
(and)Tj
1.7291 0 Td
(with)Tj
2.0012 0 Td
(time-point)Tj
4.5128 0 Td
(measures)Tj
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(at)Tj
0.9524 0 Td
(5,)Tj
0.9184 0 Td
(9)Tj
0.6973 0 Td
(and)Tj
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(20)Tj
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5.5615 0 Td
(mice)Tj
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(as)Tj
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(negative)Tj
3.532 0 Td
(control.)Tj
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(lungs)Tj
2.3698 0 Td
(and)Tj
1.7291 0 Td
(liver)Tj
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3.7474 0 Td
(aseptically.)Tj
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(enumerated)Tj
5.0172 0 Td
(by)Tj
1.1849 0 Td
(plating)Tj
2.9934 0 Td
(serial)Tj
2.3244 0 Td
(threefold)Tj
3.8324 0 Td
(organ)Tj
2.5455 0 Td
(dilutions)Tj
-33.8907 -1.3039 Td
(in)Tj
1.0318 0 Td
(duplicate)Tj
3.8891 0 Td
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1.2756 0 Td
(solid)Tj
2.1259 0 Td
(Middlebrook)Tj
5.4936 0 Td
(7H11)Tj
2.4151 0 Td
(agar)Tj
1.9275 0 Td
(supplemented)Tj
5.8506 0 Td
(with)Tj
2.0012 0 Td
(10%)Tj
1.9276 0 Td
(OADC.)Tj
3.2768 0 Td
(Petri)Tj
2.1373 0 Td
(dishes)Tj
-33.3521 -1.2983 Td
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2.1203 0 Td
(incubated)Tj
4.1782 0 Td
(for)Tj
1.389 0 Td
(14)Tj
1.1679 0 Td
(days)Tj
1.9955 0 Td
(at)Tj
0.9525 0 Td
(39C)Tj
2.228 0 Td
(and)Tj
1.7291 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(colonies)Tj
3.5035 0 Td
(were)Tj
2.1259 0 Td
(counted)Tj
3.4753 0 Td
(visually.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 496.6866 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Cytokine)Tj
4.063 0 Td
(production)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 479.6787 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
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3.2144 0 Td
(were)Tj
2.1203 0 Td
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(5)Tj
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(20)Tj
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(post-infection)Tj
5.828 0 Td
(and)Tj
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(homogenized)Tj
5.6523 0 Td
(using)Tj
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(a)Tj
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(loosely)Tj
-34.3726 -1.2982 Td
(fitting)Tj
2.6532 0 Td
(Dounce)Tj
3.3845 0 Td
(homogenizer.)Tj
5.7203 0 Td
(Leucocytes)Tj
4.5978 0 Td
(\(4)Tj
1.0374 0 Td
(x)Tj
0.686 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 390.3307 471.1181 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(6)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 396.0566 466.696 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(cells/mL)Tj
3.6113 0 Td
(as)Tj
1.0148 0 Td
(measured)Tj
4.1045 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(Coulter)Tj
3.2599 0 Td
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-33.2841 -1.2982 Td
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(cultivated)Tj
4.1215 0 Td
(at)Tj
0.9524 0 Td
(37C)Tj
2.2281 0 Td
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1.0374 0 Td
(a)Tj
0.652 0 Td
(humidified)Tj
4.6601 0 Td
(CO)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 371.8488 452.0125 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 377.6314 453.7133 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(incubator)Tj
4.1045 0 Td
(in)Tj
1.0318 0 Td
(round-bottom)Tj
5.9924 0 Td
(microwell)Tj
4.2066 0 Td
(plates)Tj
2.5001 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
-36.6346 -1.3039 Td
(volume)Tj
3.1974 0 Td
(of)Tj
1.0148 0 Td
(200)Tj
/F18 1 Tf
1.6498 0 Td
[()]TJ
/F9 1 Tf
(L)Tj
1.2642 0 Td
(RPMI-1640)Tj
4.8869 0 Td
(medium)Tj
3.6057 0 Td
(\(Life)Tj
2.0749 0 Td
(Technologies,)Tj
5.7542 0 Td
(Carlsbad,)Tj
3.9912 0 Td
(CA,)Tj
1.7915 0 Td
(USA\))Tj
2.4547 0 Td
(supplemented)Tj
-31.6853 -1.2982 Td
(with)Tj
1.9956 0 Td
(5)Tj
0.6973 0 Td
(x)Tj
0.6859 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 243.2692 432.17 cm
BT
/F18 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
/F9 1 Tf
(5)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 253.3039 427.6913 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(M)Tj
1.1111 0 Td
(2-mercaptoethano)Tj
7.3644 0 Td
(l,)Tj
0.6916 0 Td
(1%)Tj
1.4514 0 Td
(penicillin-streptomycin)Tj
9.615 0 Td
(and)Tj
1.7291 0 Td
(10%)Tj
1.9276 0 Td
(fetal)Tj
1.9105 0 Td
(calf)Tj
1.6158 0 Td
(serum)Tj
-32.7456 -1.2982 Td
(\(FCS\).)Tj
2.7893 0 Td
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2.8572 0 Td
(cells)Tj
1.9219 0 Td
(of)Tj
1.0148 0 Td
(five)Tj
1.6498 0 Td
(mice)Tj
2.1543 0 Td
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1.5307 0 Td
(group)Tj
2.6078 0 Td
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(analysed)Tj
3.651 0 Td
(individually.)Tj
5.21 0 Td
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2.16 0 Td
(were)Tj
2.126 0 Td
(stimulated)Tj
-31.7988 -1.2983 Td
(with)Tj
1.9956 0 Td
(Culture)Tj
3.2769 0 Td
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3.0896 0 Td
(\(CF\))Tj
2.092 0 Td
(of)Tj
/F14 1 Tf
1.0148 0 Td
[()28()12()]TJ
/F9 1 Tf
2.0522 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(])Tj
1.8482 0 Td
(or)Tj
1.0998 0 Td
(with)Tj
1.9956 0 Td
(purified)Tj
3.4129 0 Td
(recombinant)Tj
/F14 1 Tf
5.3688 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F14 1 Tf
0.9921 0 Td
[()7()10()12(\n)]TJ
/F9 1 Tf
(-expressed)Tj
/F14 1 Tf
5.7827 0 Td
[()28()12()]TJ
/F9 1 Tf
-34.0212 -1.3039 Td
(proteins)Tj
3.515 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
0.652 0 Td
(final)Tj
2.0011 0 Td
(concentration)Tj
5.8224 0 Td
(of)Tj
1.0148 0 Td
(5)Tj
/F18 1 Tf
0.6973 0 Td
[()]TJ
/F9 1 Tf
(g/mL)Tj
2.8743 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
3.2541 0 Td
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3.2825 0 Td
(supernatants)Tj
5.3405 0 Td
(were)Tj
2.1259 0 Td
(harvested)Tj
4.0366 0 Td
(after)Tj
-35.5689 -1.2983 Td
(72h.)Tj
1.9219 0 Td
(Supernatants)Tj
5.4594 0 Td
(were)Tj
2.1203 0 Td
(stored)Tj
2.7099 0 Td
(frozen)Tj
2.7723 0 Td
(at)Tj
0.9524 0 Td
(-20C)Tj
2.5795 0 Td
(until)Tj
2.1033 0 Td
(analysis.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 343.8425 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Cytokine)Tj
4.063 0 Td
(ELISA)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 326.8346 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(IFN-)Tj
/F16 1 Tf
(\r)Tj
/F9 1 Tf
(,)Tj
2.8516 0 Td
(IL-10)Tj
2.4037 0 Td
(and)Tj
1.7292 0 Td
(IL-17A)Tj
3.084 0 Td
(were)Tj
2.1203 0 Td
(quantified)Tj
4.3087 0 Td
(in)Tj
1.0375 0 Td
(72h)Tj
1.7007 0 Td
(culture)Tj
3.0388 0 Td
(supernatants)Tj
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(spleen)Tj
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(cell)Tj
1.5591 0 Td
(cultures)Tj
-32.9327 -1.2982 Td
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(a)Tj
0.6576 0 Td
(sandwich)Tj
3.9912 0 Td
(enzyme-linked)Tj
6.1625 0 Td
(immunosorbent)Tj
6.7294 0 Td
(assay)Tj
2.262 0 Td
(\(ELISA\).)Tj
3.7361 0 Td
(IFN-)Tj
/F16 1 Tf
(\r)Tj
/F9 1 Tf
2.6248 0 Td
(was)Tj
1.7008 0 Td
(detected)Tj
3.566 0 Td
(using)Tj
-33.8171 -1.2983 Td
(coating)Tj
3.1634 0 Td
(antibody)Tj
3.7644 0 Td
(R4-6A2)Tj
3.2995 0 Td
(and)Tj
1.7348 0 Td
(biotinylated)Tj
4.9946 0 Td
(detection)Tj
3.9401 0 Td
(antibody)Tj
3.7644 0 Td
(XMG1.2)Tj
3.6567 0 Td
(\(BD)Tj
1.8765 0 Td
(Pharmingen,)Tj
-30.1944 -1.3039 Td
(Franklin)Tj
3.6566 0 Td
(Lakes,)Tj
2.6986 0 Td
(NJ,)Tj
1.5137 0 Td
(USA\).)Tj
2.6815 0 Td
(Plates)Tj
2.5399 0 Td
(were)Tj
2.1259 0 Td
(revealed)Tj
3.5206 0 Td
(with)Tj
2.0013 0 Td
(O-phenylenediamine)Tj
8.7193 0 Td
(dihydrochloride)Tj
-29.4574 -1.2983 Td
(substrate)Tj
3.7984 0 Td
(\(OPD;)Tj
2.8289 0 Td
(Sigma-Aldrich,)Tj
6.3042 0 Td
(St.)Tj
1.2189 0 Td
(Louis,)Tj
2.6476 0 Td
(MO,)Tj
2.0862 0 Td
(USA\);)Tj
2.6816 0 Td
(the)Tj
1.4683 0 Td
(reaction)Tj
3.4923 0 Td
(was)Tj
1.7008 0 Td
(stopped)Tj
3.3732 0 Td
(with)Tj
1.9956 0 Td
(1)Tj
0.6973 0 Td
(M)Tj
-34.2933 -1.2982 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 207.6661 260.1637 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 211.2377 261.8645 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(SO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 223.4834 260.1637 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 226.9984 261.8645 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(optical)Tj
2.914 0 Td
(density)Tj
3.1011 0 Td
(was)Tj
1.7007 0 Td
(read)Tj
1.9729 0 Td
(at)Tj
0.9525 0 Td
(490)Tj
1.6497 0 Td
(nm.)Tj
1.8142 0 Td
(IL-10)Tj
2.3981 0 Td
(and)Tj
1.7291 0 Td
(IL-17A)Tj
3.0841 0 Td
(were)Tj
2.126 0 Td
(detected)Tj
3.5659 0 Td
(with)Tj
1.9956 0 Td
(com-)Tj
-35.3477 -1.3039 Td
(mercial)Tj
3.203 0 Td
(ELISA)Tj
2.829 0 Td
(kits)Tj
1.6441 0 Td
(\(eBioscience,)Tj
5.4311 0 Td
(San)Tj
1.6781 0 Td
(Diego,)Tj
2.846 0 Td
(CA,)Tj
1.7915 0 Td
(USA\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 217.0204 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Characteristics)Tj
6.7559 0 Td
(of)Tj
1.0488 0 Td
(35)Tj
1.3134 0 Td
(recombinant)Tj
/F8 1 Tf
5.6599 0 Td
(Map)Tj
/F0 1 Tf
2.1449 0 Td
(proteins)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 200.0125 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(list)Tj
1.3946 0 Td
(of)Tj
1.0148 0 Td
(35)Tj
/F14 1 Tf
1.1679 0 Td
[()28()12()]TJ
/F9 1 Tf
2.0579 0 Td
(proteins)Tj
3.5093 0 Td
(is)Tj
0.8504 0 Td
(given)Tj
2.3811 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0318 0 Td
(Table)Tj
2.4434 0 Td
(2)Tj
0 g
(.)Tj
0.9241 0 Td
(Antigens)Tj
3.8154 0 Td
(118)Tj
2.16 0 Td
(were)Tj
2.126 0 Td
(previously)Tj
4.3483 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
-35.0643 -1.3039 Td
(proteomic)Tj
4.3539 0 Td
(and)Tj
1.7292 0 Td
(immunoproteomic)Tj
7.8462 0 Td
(analysis)Tj
3.3222 0 Td
(of)Tj
1.0148 0 Td
(standard)Tj
/F14 1 Tf
3.7247 0 Td
[()28()12()]TJ
/F9 1 Tf
2.0523 0 Td
(biofilm)Tj
3.1237 0 Td
(culture)Tj
3.0387 0 Td
(filtrate)Tj
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(of)Tj
1.0148 0 Td
(bacteria)Tj
-34.0665 -1.2982 Td
(grown)Tj
2.7949 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(surface)Tj
3.05 0 Td
(pellicle)Tj
3.0161 0 Td
(on)Tj
1.2755 0 Td
(synthetic)Tj
3.8211 0 Td
(Sauton)Tj
3.0104 0 Td
(medium)Tj
3.6056 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.075 0 Td
(Antigens)Tj
3.8211 0 Td
(1924)Tj
2.6362 0 Td
(were)Tj
2.1259 0 Td
(identified)Tj
-32.8986 -1.2983 Td
(using)Tj
2.3867 0 Td
(an)Tj
/F14 1 Tf
1.2019 0 Td
[(\n)12()]TJ
1.0148 0 Td
[()10(\n)4()12(\n)4()7()]TJ
/F9 1 Tf
2.16 0 Td
(analysis)Tj
3.3222 0 Td
(of)Tj
/F14 1 Tf
1.0148 0 Td
[()28()12()]TJ
/F9 1 Tf
2.0579 0 Td
(genome)Tj
3.4072 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
2.075 0 Td
(Finally,)Tj
3.1691 0 Td
(antigens)Tj
3.5659 0 Td
(2535)Tj
2.6419 0 Td
(were)Tj
2.1203 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
-34.1969 -1.2983 Td
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0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
BT
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1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.2614 0 Td
(List)Tj
1.9772 0 Td
(of)Tj
1.1551 0 Td
(35)Tj
1.3111 0 Td
(recombi)Tj
3.8338 0 Td
(nant)Tj
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2.3103 0 Td
(M)Tj
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(.)Tj
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1.3252 0 Td
(avium)Tj
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3.0685 0 Td
(subsp.)Tj
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3.4087 0 Td
(paratuber)Tj
4.5426 0 Td
(culosis)Tj
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3.6213 0 Td
(antigens.)Tj
0 Tc
-30.6144 -1.8567 Td
(Nr.)Tj
4.2945 0 Td
(Antigen)Tj
20.7143 0 Td
(Descriptio)Tj
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(n)Tj
15.7253 0 Td
(E)Tj
0.9 0 Td
(value)Tj
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(Ident.)Tj
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(Accessio)Tj
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(Myco)Tj
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-63.0288 -1.6228 Td
(1)Tj
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3.2527 0 Td
(MAP0139c)Tj
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7.2568 0 Td
(transcript)Tj
4.089 0 Td
(ional)Tj
2.3173 0 Td
(regulator,)Tj
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(PadR)Tj
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(family)Tj
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(protein)Tj
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([Mycobacte)Tj
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(rium)Tj
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(104])Tj
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(8,00E-)Tj
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(144)Tj
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(99%)Tj
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(ABK65)Tj
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(696.1)Tj
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4.9252 0 Td
(MAA104)Tj
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(2)Tj
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(MAP0586c)Tj
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7.2568 0 Td
(transglycos)Tj
5.0244 0 Td
(ylase)Tj
2.5442 0 Td
(SLT)Tj
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(domain)Tj
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(protein)Tj
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([Mycobact)Tj
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(erium)Tj
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3.5291 0 Td
(MAP0907)Tj
/F0 1 Tf
6.9804 0 Td
(morphin)Tj
3.5788 0 Td
(e)Tj
0.7866 0 Td
(6-dehy)Tj
3.026 0 Td
(drogenase)Tj
4.9181 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
13.6844 0 Td
(0)Tj
3.3732 0 Td
(98%)Tj
4.3229 0 Td
(ABK68)Tj
3.0898 0 Td
(334.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -1.5662 Td
(MAP0907)Tj
/F0 1 Tf
6.9804 0 Td
(oxidoreduc)Tj
4.8473 0 Td
(tase)Tj
2.1118 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
2.4945 0 Td
(TH135])Tj
9.2765 0 Td
(1,00E-)Tj
0.9142 -1.1834 Td
(52)Tj
3.6496 1.1834 Td
(41%)Tj
4.2945 0 Td
(BAN3296)Tj
4.2449 0 Td
(6.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1834 Td
(TH135)Tj
/F0 1 Tf
-62.8091 -1.5662 Td
(4)Tj
/F3 1 Tf
3.2527 0 Td
(MAP1438c)Tj
/F0 1 Tf
7.2568 0 Td
(alpha/beta)Tj
4.8615 0 Td
(hydrolase)Tj
4.5283 0 Td
(fold)Tj
1.8284 0 Td
(domain)Tj
3.4795 0 Td
(protein)Tj
3.267 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0394 0 Td
(avium)Tj
2.8843 0 Td
(104])Tj
8.0292 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK65)Tj
3.0898 0 Td
(668.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-59.0887 -1.559 Td
(MAP1438c)Tj
/F0 1 Tf
7.2568 0 Td
(alpha/beta)Tj
4.8615 0 Td
(hydrolase)Tj
4.5283 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(homini)Tj
2.9127 0 Td
(ssuis)Tj
2.4945 0 Td
(TH135])Tj
6.8457 0 Td
(2,00E-)Tj
0.9142 -1.1906 Td
(24)Tj
3.6496 1.1906 Td
(40%)Tj
4.2945 0 Td
(BAN3344)Tj
4.2449 0 Td
(0.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1906 Td
(TH135)Tj
/F0 1 Tf
-62.8091 -1.5591 Td
(5)Tj
/F3 1 Tf
3.2527 0 Td
(MAP1562c)Tj
/F0 1 Tf
7.2568 0 Td
(conserve)Tj
4.0252 0 Td
(d)Tj
0.7866 0 Td
(hypothet)Tj
3.8056 0 Td
(ical)Tj
1.715 0 Td
(protein)Tj
3.2669 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
11.204 0 Td
(1,00E-)Tj
0.9142 -1.1905 Td
(89)Tj
3.3732 1.1905 Td
(100%)Tj
4.5993 0 Td
(ABK66)Tj
3.0898 0 Td
(813.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.3414 -2.7567 Td
(6)Tj
/F3 1 Tf
2.4732 0 Td
(MAP1693c-F)Tj
5.9103 0 Td
(L)Tj
/F0 1 Tf
2.126 0 Td
(peptidyl-pr)Tj
4.6276 0 Td
(olyl)Tj
1.715 0 Td
(cis-trans)Tj
3.9898 0 Td
(isomerase,)Tj
5.0953 0 Td
(fkbp-typ)Tj
3.5362 0 Td
(e)Tj
0.7796 0 Td
(domain)Tj
3.4795 0 Td
(protein)Tj
3.267 0 Td
([Mycob)Tj
3.2031 0 Td
(acterium)Tj
-29.6931 -1.1835 Td
(avium)Tj
2.8772 0 Td
(104])Tj
32.053 1.1835 Td
(1,00E-)Tj
0.6449 -1.1835 Td
(125)Tj
3.9189 1.1835 Td
(98%)Tj
4.3229 0 Td
(ABK64)Tj
3.0898 0 Td
(725.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-59.8682 -2.7496 Td
(MAP1693c-F)Tj
5.9103 0 Td
(L)Tj
/F0 1 Tf
2.126 0 Td
(peptidyl-pr)Tj
4.6276 0 Td
(olyl)Tj
1.715 0 Td
(cis-trans)Tj
3.9898 0 Td
(isomerase)Tj
4.8118 0 Td
(domain-con)Tj
5.1804 0 Td
(taining)Tj
3.1464 0 Td
(protein)Tj
-23.471 -1.1835 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8771 0 Td
(subsp.)Tj
3.1607 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
2.4945 0 Td
(TH135])Tj
16.2356 1.1835 Td
(4,00E-)Tj
0.6449 -1.1835 Td
(113)Tj
3.6425 1.1835 Td
(100%)Tj
4.5709 0 Td
(BAN3162)Tj
4.2449 0 Td
(9.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1835 Td
(TH135)Tj
/F0 1 Tf
-62.8091 -1.5661 Td
(7)Tj
/F3 1 Tf
3.5291 0 Td
(MAP2411)Tj
/F0 1 Tf
6.9804 0 Td
(pyridoxam)Tj
4.578 0 Td
(ine)Tj
1.552 0 Td
(5-phosp)Tj
3.5787 0 Td
(hate)Tj
2.1615 0 Td
(oxidase)Tj
3.6496 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
-25.6467 -1.1835 Td
(hominiss)Tj
3.9118 0 Td
(uis)Tj
1.5024 0 Td
(104249)Tj
3.8481 0 Td
(])Tj
25.6679 1.1835 Td
(9,00E-)Tj
0.6449 -1.1835 Td
(101)Tj
3.6425 1.1835 Td
(100%)Tj
4.6205 0 Td
(ETB30907.)Tj
4.9749 0 Td
(1)Tj
/F3 1 Tf
3.848 0 Td
(MAH)Tj
/F0 1 Tf
-63.1705 -2.7497 Td
(8)Tj
/F3 1 Tf
3.2527 0 Td
(MAP2677c)Tj
/F0 1 Tf
7.2568 0 Td
(glyoxalas)Tj
4.1315 0 Td
(e)Tj
0.7796 0 Td
(family)Tj
2.8275 0 Td
(protein)Tj
3.2599 0 Td
([Mycobacte)Tj
5.0882 0 Td
(rium)Tj
2.1615 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
13.8048 0 Td
(8,00E-)Tj
0.9142 -1.1835 Td
(92)Tj
3.6496 1.1835 Td
(98%)Tj
4.3229 0 Td
(ABK69)Tj
3.0898 0 Td
(112.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.3414 -2.7496 Td
(9)Tj
/F3 1 Tf
3.5291 0 Td
(MAP2746)Tj
/F0 1 Tf
6.9804 0 Td
(hypotheti)Tj
4.0252 0 Td
(cal)Tj
1.5024 0 Td
(protein)Tj
3.2599 0 Td
(MAH_1788)Tj
5.1945 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8771 0 Td
(subsp.)Tj
3.1607 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
-30.1821 -1.1835 Td
(TH135])Tj
34.9302 1.1835 Td
(4,00E-)Tj
0.6449 -1.1835 Td
(119)Tj
3.9189 1.1835 Td
(98%)Tj
4.2945 0 Td
(BAN3086)Tj
4.2449 0 Td
(2.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1835 Td
(TH135)Tj
-59.28 -1.5661 Td
(MAP2746)Tj
/F0 1 Tf
6.9804 0 Td
(conserve)Tj
4.0252 0 Td
(d)Tj
0.7866 0 Td
(hypothet)Tj
3.8056 0 Td
(ical)Tj
1.715 0 Td
(protein)Tj
3.2669 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
11.204 0 Td
(2,00E-)Tj
0.6449 -1.1835 Td
(109)Tj
3.9189 1.1835 Td
(99%)Tj
4.3229 0 Td
(ABK64)Tj
3.0898 0 Td
(828.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7497 Td
(10)Tj
/F3 1 Tf
2.1472 0 Td
(MAP-CF)Tj
3.8694 0 Td
(036-Ag3)Tj
/F0 1 Tf
4.7693 0 Td
(integral)Tj
3.4796 0 Td
(membrane)Tj
4.9748 0 Td
(protein)Tj
3.2599 0 Td
(YrbE1A)Tj
3.6567 0 Td
([Mycobacte)Tj
5.0882 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8843 0 Td
(subsp.)Tj
-25.5049 -1.1834 Td
(hominiss)Tj
3.9118 0 Td
(uis)Tj
1.5024 0 Td
(TH135])Tj
30.2955 1.1834 Td
(3,4)Tj
3.7843 0 Td
(20%)Tj
4.2945 0 Td
(BAN3350)Tj
4.2449 0 Td
(2.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1834 Td
(TH135)Tj
-60.9383 -1.5662 Td
(MAP-CF)Tj
3.8694 0 Td
(036-Ag3)Tj
/F0 1 Tf
4.7693 0 Td
(conserve)Tj
4.0252 0 Td
(d)Tj
0.7866 0 Td
(hypothet)Tj
3.8056 0 Td
(ical)Tj
1.715 0 Td
(protein)Tj
3.2669 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
11.9835 0 Td
(3,4)Tj
3.7843 0 Td
(20%)Tj
4.3229 0 Td
(ABK66)Tj
3.0898 0 Td
(937.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -1.5591 Td
(11)Tj
/F3 1 Tf
3.8055 0 Td
(MAP3385)Tj
/F0 1 Tf
6.9804 0 Td
(methyltra)Tj
4.089 0 Td
(nsferase)Tj
4.0394 0 Td
([Mycobacte)Tj
5.0882 0 Td
(rium)Tj
2.1615 0 Td
(avium)Tj
2.8842 0 Td
(subsp.)Tj
3.1536 0 Td
(hominissu)Tj
4.4646 0 Td
(is)Tj
0.9496 0 Td
(TH135])Tj
8.1001 0 Td
(8,00E-)Tj
0.9142 -1.1905 Td
(65)Tj
3.6496 1.1905 Td
(64%)Tj
4.2945 0 Td
(BAN3292)Tj
4.2449 0 Td
(4.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1905 Td
(TH135)Tj
-59.28 -1.5591 Td
(MAP3385)Tj
/F0 1 Tf
6.9804 0 Td
(hypotheti)Tj
4.0252 0 Td
(cal)Tj
1.5024 0 Td
(protein)Tj
3.2599 0 Td
(MAH_3962)Tj
5.1945 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8771 0 Td
(subsp.)Tj
3.1607 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
-30.1821 -1.1905 Td
(TH135])Tj
34.9302 1.1905 Td
(2,00E-)Tj
0.9142 -1.1905 Td
(64)Tj
3.6496 1.1905 Td
(44%)Tj
4.2945 0 Td
(BAN3303)Tj
4.2449 0 Td
(6.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1905 Td
(TH135)Tj
-59.28 -1.5662 Td
(MAP3385)Tj
/F0 1 Tf
6.9804 0 Td
(methyltra)Tj
4.089 0 Td
(nsferase,)Tj
4.3229 0 Td
(putative,)Tj
3.9898 0 Td
(family)Tj
2.8275 0 Td
(protein)Tj
3.2599 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
6.3142 0 Td
(5,00E-)Tj
0.9142 -1.1835 Td
(32)Tj
3.6496 1.1835 Td
(40%)Tj
4.3229 0 Td
(ABK67)Tj
3.0898 0 Td
(089.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7496 Td
(12)Tj
/F3 1 Tf
3.8055 0 Td
(MAP3486)Tj
/F0 1 Tf
6.9804 0 Td
(lactate)Tj
3.1606 0 Td
(2-mono)Tj
3.3591 0 Td
(oxygenase)Tj
5.0316 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
14.4427 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK65)Tj
3.0898 0 Td
(670.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -1.5591 Td
(MAP3486)Tj
/F0 1 Tf
6.9804 0 Td
(LldD2)Tj
2.8134 0 Td
(protein)Tj
3.267 0 Td
([Mycob)Tj
3.2031 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1536 0 Td
(hominissu)Tj
4.4646 0 Td
(is)Tj
0.9496 0 Td
(TH135])Tj
10.1552 0 Td
(4,00E-)Tj
0.9142 -1.1906 Td
(35)Tj
3.6496 1.1906 Td
(32%)Tj
4.2945 0 Td
(BAN3152)Tj
4.2449 0 Td
(0.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1906 Td
(TH135)Tj
/F0 1 Tf
-63.0855 -1.559 Td
(13)Tj
/F3 1 Tf
3.5291 0 Td
(MAP3547c)Tj
/F0 1 Tf
7.2568 0 Td
(hypotheti)Tj
4.0252 0 Td
(cal)Tj
1.5024 0 Td
(protein)Tj
3.2599 0 Td
(MAV3388)Tj
4.3583 0 Td
(_23345)Tj
3.5362 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
-26.8089 -1.1906 Td
(hominiss)Tj
3.9118 0 Td
(uis)Tj
1.5024 0 Td
(3388])Tj
30.7066 1.1906 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.2378 0 Td
(KDO9244)Tj
4.3583 0 Td
(9.1)Tj
/F3 1 Tf
4.5709 0 Td
(MAH)Tj
-59.9178 -2.7496 Td
(MAP3547c)Tj
/F0 1 Tf
7.2568 0 Td
(conserve)Tj
4.0252 0 Td
(d)Tj
0.7866 0 Td
(hypothet)Tj
3.8056 0 Td
(ical)Tj
1.715 0 Td
(protein)Tj
3.2669 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
11.204 0 Td
(2,00E-)Tj
0.9142 -1.1906 Td
(17)Tj
3.6496 1.1906 Td
(26%)Tj
4.3229 0 Td
(ABK65)Tj
3.0898 0 Td
(078.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7497 Td
(14)Tj
/F3 1 Tf
3.5291 0 Td
(MAP3680c)Tj
/F0 1 Tf
7.2568 0 Td
(Formate)Tj
3.9402 0 Td
(dehyd)Tj
2.6929 0 Td
(rogenase)Tj
4.3654 0 Td
([Mycobact)Tj
4.5355 0 Td
(erium)Tj
2.7142 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(hominiss)Tj
3.9119 0 Td
(uis)Tj
1.4952 0 Td
(TH135])Tj
6.4277 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.2945 0 Td
(BAN3341)Tj
4.2449 0 Td
(5.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1905 Td
(TH135)Tj
-59.5564 -1.5591 Td
(MAP3680c)Tj
/F0 1 Tf
7.2568 0 Td
(formate)Tj
3.6071 0 Td
(dehydr)Tj
3.026 0 Td
(ogenase)Tj
4.0323 0 Td
([Mycobacte)Tj
5.0883 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
15.3285 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK68)Tj
3.0898 0 Td
(013.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -1.5662 Td
(15)Tj
/F3 1 Tf
3.5291 0 Td
(MAP3731c)Tj
/F0 1 Tf
7.2568 0 Td
(O-antigen)Tj
4.5922 0 Td
(export)Tj
2.9905 0 Td
(system)Tj
3.3875 0 Td
(ATP-bindi)Tj
4.3583 0 Td
(ng)Tj
1.3323 0 Td
(protein)Tj
3.2598 0 Td
(RfbB)Tj
2.4449 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
-29.6152 -1.1834 Td
(104])Tj
35.4333 1.1834 Td
(0,13)Tj
4.0607 0 Td
(21%)Tj
4.3229 0 Td
(ABK65)Tj
3.0898 0 Td
(477.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-59.0887 -2.7496 Td
(MAP3731c)Tj
/F0 1 Tf
7.2568 0 Td
(O-antigen)Tj
4.5922 0 Td
(export)Tj
2.9905 0 Td
(system)Tj
3.3875 0 Td
(ATP-bindi)Tj
4.3583 0 Td
(ng)Tj
1.3323 0 Td
(protein)Tj
3.2598 0 Td
(RfbB)Tj
2.4449 0 Td
([Mycoba)Tj
3.756 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
-29.6152 -1.1835 Td
(subsp.)Tj
3.1606 0 Td
(homini)Tj
2.9127 0 Td
(ssuis)Tj
2.4945 0 Td
(TH135])Tj
26.8655 1.1835 Td
(0,16)Tj
4.0607 0 Td
(21%)Tj
4.2945 0 Td
(BAN2932)Tj
4.2449 0 Td
(6.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1835 Td
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472.989 664.4409 m
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h
f*
464.485 642.4441 m
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h
f*
473.9528 598.4504 m
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f*
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f*
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f*
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390.6142 187.2 m
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h
f*
78.463 175.1811 m
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h
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.4913 cm
BT
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1 TL
0 0 Td
(Table)Tj
2.8346 0 Td
(2.)Tj
/F0 1 Tf
1.3323 0 Td
(\()Tj
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(Continue)Tj
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(d)Tj
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(n)Tj
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(E)Tj
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(value)Tj
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(Myco)Tj
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(MAP4308c)Tj
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(fructose-)Tj
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(bisphosphate)Tj
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(aldolase)Tj
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(class-I)Tj
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(104])Tj
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(0)Tj
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(MAP_374)Tj
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(K-10])Tj
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(0)Tj
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(99%)Tj
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4.3229 0 Td
(AAS06)Tj
3.0898 0 Td
(293.1)Tj
0 g
/F3 1 Tf
5.7827 0 Td
(MAP)Tj
/F0 1 Tf
-63.4753 -2.7497 Td
(24)Tj
/F3 1 Tf
3.1961 0 Td
(MAP3744m-)Tj
1.6016 -1.1834 Td
(Ag10)Tj
/F0 1 Tf
5.9882 1.1834 Td
(thiazoliny)Tj
4.1315 0 Td
(l)Tj
0.4465 0 Td
(imide)Tj
2.6008 0 Td
(reductase)Tj
4.5922 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1607 0 Td
(paratub)Tj
3.359 0 Td
(erculosis)Tj
-28.4175 -1.1834 Td
(104404])Tj
36.1208 1.1834 Td
(0)Tj
3.3732 0 Td
(99%)Tj
0.83 0.64 0.02 0 k
4.3441 0 Td
(ETB06990.)Tj
4.9749 0 Td
(1)Tj
0 g
/F3 1 Tf
3.8764 0 Td
(MAP)Tj
/F0 1 Tf
-63.4753 -2.7496 Td
(24)Tj
/F3 1 Tf
3.1961 0 Td
(MAP3744m-)Tj
1.6016 -1.1835 Td
(Ag10)Tj
/F0 1 Tf
5.9882 1.1835 Td
(thiazoliny)Tj
4.1315 0 Td
(l)Tj
0.4465 0 Td
(imide)Tj
2.6008 0 Td
(reductase)Tj
4.5922 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4937 0 Td
(avium])Tj
17.1002 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
3.1394 0 Td
(WP_016)Tj
3.8055 0 Td
(705779.1)Tj
/F17 1 Tf
5.2442 0 Td
(M)Tj
/F3 1 Tf
(.)Tj
/F17 1 Tf
1.3394 0 Td
(avium)Tj
/F0 1 Tf
-63.8084 -2.7496 Td
(25)Tj
/F3 1 Tf
3.8055 0 Td
(MAP0217)Tj
/F0 1 Tf
6.9804 0 Td
(antigen)Tj
3.4796 0 Td
(85-C)Tj
2.3811 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
18.9427 0 Td
(7,00E-)Tj
0.6449 -1.1835 Td
(180)Tj
3.9189 1.1835 Td
(99%)Tj
4.3229 0 Td
(ABK64)Tj
3.0898 0 Td
(781.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -2.7497 Td
(MAP0217)Tj
/F0 1 Tf
6.9804 0 Td
(antigen)Tj
3.4796 0 Td
(85-C)Tj
2.3811 0 Td
(protein)Tj
3.2598 0 Td
([Mycobact)Tj
4.5355 0 Td
(erium)Tj
2.7142 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(hominiss)Tj
3.9119 0 Td
(uis)Tj
1.4953 0 Td
(TH135])Tj
7.115 0 Td
(3,00E-)Tj
0.6449 -1.1834 Td
(179)Tj
3.9189 1.1834 Td
(99%)Tj
4.2945 0 Td
(BAN2930)Tj
4.2449 0 Td
(3.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1834 Td
(TH135)Tj
/F0 1 Tf
-63.0855 -1.5662 Td
(26)Tj
/F3 1 Tf
3.8055 0 Td
(MAP0353)Tj
/F0 1 Tf
6.9804 0 Td
(glycerol)Tj
3.6425 0 Td
(kinase)Tj
3.0969 0 Td
([Mycobacte)Tj
5.0882 0 Td
(rium)Tj
2.1615 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
19.2545 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK67)Tj
3.0898 0 Td
(587.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -1.5591 Td
(27)Tj
/F3 1 Tf
3.8055 0 Td
(MAP1166)Tj
/F0 1 Tf
6.9804 0 Td
(RecName:)Tj
4.9252 0 Td
(Full)Tj
1.8284 0 Td
(=)Tj
0.8079 0 Td
(Triosephos)Tj
4.911 0 Td
(phate)Tj
2.7142 0 Td
(isomerase)Tj
4.578 0 Td
(;)Tj
0.5103 0 Td
(Short)Tj
2.6079 0 Td
(=)Tj
0.8149 0 Td
(TIM;)Tj
2.2323 0 Td
(Short)Tj
2.6079 0 Td
(=)Tj
0.815 0 Td
(TPI;)Tj
-29.353 -1.1905 Td
(AltName:)Tj
4.3229 0 Td
(Full)Tj
1.8283 0 Td
(=)Tj
0.8079 0 Td
(Triose-phos)Tj
5.2441 0 Td
(phate)Tj
2.7142 0 Td
(isomeras)Tj
4.0253 0 Td
(e)Tj
17.1781 1.1905 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.7268 0 Td
(A0QHY3.1)Tj
/F3 1 Tf
7.6111 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7496 Td
(28)Tj
/F3 1 Tf
3.8055 0 Td
(MAP1362)Tj
/F0 1 Tf
6.9804 0 Td
(arginine)Tj
3.7488 0 Td
(biosynthe)Tj
4.245 0 Td
(sis)Tj
1.4456 0 Td
(bifunctiona)Tj
4.7977 0 Td
(l)Tj
0.4536 0 Td
(protein)Tj
3.2598 0 Td
(ArgJ)Tj
2.2749 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4937 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
4.578 0 Td
(9,00E-)Tj
0.6449 -1.1905 Td
(145)Tj
3.9189 1.1905 Td
(99%)Tj
4.3229 0 Td
(ABK65)Tj
3.0898 0 Td
(024.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7496 Td
(29)Tj
/F3 1 Tf
3.8055 0 Td
(MAP1803)Tj
/F0 1 Tf
6.9804 0 Td
(dienelacto)Tj
4.5142 0 Td
(ne)Tj
1.3323 0 Td
(hydrolase)Tj
4.5284 0 Td
([Mycobacte)Tj
5.0882 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
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(subsp.)Tj
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(hominiss)Tj
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(uis)Tj
1.5024 0 Td
(TH135])Tj
5.8536 0 Td
(4,00E-)Tj
0.6449 -1.1906 Td
(166)Tj
3.9189 1.1906 Td
(99%)Tj
4.2945 0 Td
(BAN3176)Tj
4.2449 0 Td
(5.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1906 Td
(TH135)Tj
-59.28 -1.559 Td
(MAP1803)Tj
/F0 1 Tf
6.9804 0 Td
(dienelacto)Tj
4.5142 0 Td
(ne)Tj
1.3323 0 Td
(hydrolase)Tj
4.5284 0 Td
(family)Tj
2.8276 0 Td
(protein)Tj
3.2598 0 Td
([Mycobacte)Tj
5.0883 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
8.341 0 Td
(2,00E-)Tj
0.6449 -1.1906 Td
(143)Tj
3.9189 1.1906 Td
(99%)Tj
4.3229 0 Td
(ABK69)Tj
3.0898 0 Td
(268.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -2.7567 Td
(30)Tj
/F3 1 Tf
3.8055 0 Td
(MAP2800)Tj
/F0 1 Tf
6.9804 0 Td
(enoyl-CoA)Tj
4.8615 0 Td
(hydratase)Tj
4.5921 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
16.5403 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK64)Tj
3.0898 0 Td
(508.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -1.5591 Td
(MAP2800)Tj
/F0 1 Tf
6.9804 0 Td
(enoyl-CoA)Tj
4.8615 0 Td
(hydratase)Tj
4.5921 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
2.4945 0 Td
(TH135])Tj
6.782 0 Td
(2,00E-)Tj
0.9142 -1.1906 Td
(24)Tj
3.6496 1.1906 Td
(30%)Tj
4.2945 0 Td
(BAN3013)Tj
4.2449 0 Td
(7.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1906 Td
(TH135)Tj
/F0 1 Tf
-63.0855 -1.559 Td
(31)Tj
/F3 1 Tf
3.5291 0 Td
(MAP2864c)Tj
/F0 1 Tf
7.2568 0 Td
(dihydrodipi)Tj
4.7835 0 Td
(colinate)Tj
3.6496 0 Td
(synthase)Tj
4.2095 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
13.3513 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK66)Tj
3.0898 0 Td
(322.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -1.5662 Td
(32)Tj
/F3 1 Tf
3.8055 0 Td
(MAP3413)Tj
/F0 1 Tf
6.9804 0 Td
(aldehyde)Tj
4.2449 0 Td
(dehydrogenas)Tj
6.2859 0 Td
(e)Tj
0.7795 0 Td
(\(NAD\))Tj
2.9906 0 Td
(family)Tj
2.8276 0 Td
(protein)Tj
3.2598 0 Td
([Mycobacte)Tj
5.0883 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
5.6056 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK69)Tj
3.0898 0 Td
(290.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -1.5591 Td
(MAP3413)Tj
/F0 1 Tf
6.9804 0 Td
(P-cumic)Tj
3.8197 0 Td
(aldehyde)Tj
4.252 0 Td
(dehydro)Tj
3.5788 0 Td
(genase)Tj
3.4866 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0465 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1535 0 Td
(hominissu)Tj
4.4646 0 Td
(is)Tj
-32.8821 -1.1905 Td
(TH135])Tj
34.9302 1.1905 Td
(3,00E-)Tj
0.9142 -1.1905 Td
(41)Tj
3.6496 1.1905 Td
(27%)Tj
4.2945 0 Td
(BAN3159)Tj
4.2449 0 Td
(0.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1905 Td
(TH135)Tj
/F0 1 Tf
-63.0855 -1.5591 Td
(33)Tj
/F3 1 Tf
3.8055 0 Td
(MAP3634)Tj
/F0 1 Tf
6.9804 0 Td
(ErfK/YbiS)Tj
4.3158 0 Td
(/YcfS/YnhG)Tj
5.4425 0 Td
(family)Tj
2.8276 0 Td
(protein)Tj
3.267 0 Td
([Mycob)Tj
3.2032 0 Td
(acterium)Tj
4.0464 0 Td
(avium)Tj
2.8772 0 Td
(104]Lip)Tj
3.2457 0 Td
(oprotein)Tj
-29.2254 -1.1906 Td
(lprQ)Tj
36.1208 1.1906 Td
(0)Tj
3.0968 0 Td
(100%)Tj
4.5993 0 Td
(ABK64)Tj
3.0898 0 Td
(614.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
-58.8123 -2.7496 Td
(MAP3634)Tj
/F0 1 Tf
6.9804 0 Td
(hypotheti)Tj
4.0252 0 Td
(cal)Tj
1.5024 0 Td
(protein)Tj
3.2599 0 Td
(MAH_1464)Tj
5.1945 0 Td
([Mycoba)Tj
3.7559 0 Td
(cterium)Tj
3.4938 0 Td
(avium)Tj
2.8771 0 Td
(subsp.)Tj
3.1607 0 Td
(homini)Tj
2.9126 0 Td
(ssuis)Tj
-30.1821 -1.1906 Td
(TH135])Tj
34.9302 1.1906 Td
(6,00E-)Tj
0.9142 -1.1906 Td
(48)Tj
3.6496 1.1906 Td
(41%)Tj
4.2945 0 Td
(BAN3053)Tj
4.2449 0 Td
(8.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1906 Td
(TH135)Tj
/F0 1 Tf
-63.0855 -1.5591 Td
(34)Tj
/F3 1 Tf
3.5291 0 Td
(MAP3668c)Tj
/F0 1 Tf
7.2568 0 Td
(phosphotri)Tj
4.6276 0 Td
(esterase-like)Tj
5.8607 0 Td
(protein)Tj
3.2598 0 Td
([Mycobacte)Tj
5.0883 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8772 0 Td
(subsp.)Tj
3.1606 0 Td
(hominissu)Tj
4.4646 0 Td
(is)Tj
-31.5002 -1.1905 Td
(TH135])Tj
36.1208 1.1905 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.2945 0 Td
(BAN3342)Tj
4.2449 0 Td
(6.1)Tj
/F3 1 Tf
4.6276 0 Td
(MAH)Tj
-0.3614 -1.1905 Td
(TH135)Tj
-59.5564 -1.5591 Td
(MAP3668c)Tj
/F0 1 Tf
7.2568 0 Td
(phosphotri)Tj
4.6276 0 Td
(esterase-like)Tj
5.8607 0 Td
(protein)Tj
3.2598 0 Td
([Mycobacte)Tj
5.0883 0 Td
(rium)Tj
2.1614 0 Td
(avium)Tj
2.8772 0 Td
(104])Tj
12.2458 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.3229 0 Td
(ABK64)Tj
3.0898 0 Td
(738.1)Tj
/F3 1 Tf
4.9252 0 Td
(MAA104)Tj
/F0 1 Tf
-62.6178 -1.5661 Td
(35)Tj
/F3 1 Tf
3.5291 0 Td
(MAP2541c)Tj
/F0 1 Tf
7.2568 0 Td
(Malate)Tj
3.2103 0 Td
(dehydro)Tj
3.5787 0 Td
(genase)Tj
29.3318 0 Td
(0)Tj
3.3732 0 Td
(99%)Tj
4.9252 0 Td
(A0QCI6)Tj
3.5363 0 Td
(.1)Tj
/F3 1 Tf
3.8764 0 Td
(MAA104)Tj
/F0 1 Tf
-62.7595 -2.3386 Td
(Ags)Tj
1.9417 0 Td
(118:)Tj
/F8 1 Tf
2.7142 0 Td
(Map)Tj
/F0 1 Tf
2.1614 0 Td
(antigens)Tj
3.9756 0 Td
(identied)Tj
4.1954 0 Td
(by)Tj
1.2826 0 Td
(proteomic)Tj
4.5922 0 Td
(and)Tj
1.878 0 Td
(immunoprot)Tj
5.2441 0 Td
(eomic)Tj
2.8772 0 Td
(analysis)Tj
3.8126 0 Td
(of)Tj
/F8 1 Tf
1.063 0 Td
(Map)Tj
/F0 1 Tf
2.1615 0 Td
(culture)Tj
3.2102 0 Td
(ltrate)Tj
2.941 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(];)Tj
2.1685 0 Td
(Ags)Tj
1.9488 0 Td
(1924:)Tj
/F8 1 Tf
3.2599 0 Td
(Map)Tj
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2.1614 0 Td
(antigen)Tj
3.2457 0 Td
(s)Tj
0.73 0 Td
(identied)Tj
4.1953 0 Td
(by)Tj
/F8 1 Tf
1.2827 0 Td
(in)Tj
0.9992 0 Td
(silico)Tj
/F0 1 Tf
-64.0422 -1.5024 Td
(predictions)Tj
5.0244 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(];)Tj
2.1756 0 Td
(Ags)Tj
1.9418 0 Td
(2535:)Tj
/F8 1 Tf
3.2598 0 Td
(Map)Tj
/F0 1 Tf
2.1615 0 Td
(antigens)Tj
3.9827 0 Td
(identied)Tj
4.1953 0 Td
(in)Tj
/F8 1 Tf
0.9992 0 Td
(Map)Tj
/F0 1 Tf
2.1614 0 Td
(cultures)Tj
3.7064 0 Td
(submitted)Tj
4.5425 0 Td
(to)Tj
1.0559 0 Td
(stress)Tj
2.8914 0 Td
(conditions)Tj
4.4646 0 Td
(:)Tj
0.5102 0 Td
(nutrient)Tj
3.5434 0 Td
(starvatio)Tj
3.7559 0 Td
(n,)Tj
1.063 0 Td
(hypoxia)Tj
3.6496 0 Td
(or)Tj
1.1126 0 Td
(acidic)Tj
2.7638 0 Td
(pH)Tj
1.4953 0 Td
(\(Roupie)Tj
/F8 1 Tf
3.6993 0 Td
(et)Tj
1.0559 0 Td
(al)Tj
/F0 1 Tf
(.,)Tj
-65.2115 -1.5024 Td
(manuscrip)Tj
4.5779 0 Td
(t)Tj
0.5103 0 Td
(in)Tj
0.9992 0 Td
(preparatio)Tj
4.4646 0 Td
(n\).)Tj
1.3961 0 Td
(Proteins)Tj
3.8693 0 Td
(actually)Tj
3.6 0 Td
(upregula)Tj
3.8481 0 Td
(ted)Tj
1.6157 0 Td
(in)Tj
0.9993 0 Td
(stress)Tj
2.8842 0 Td
(conditions)Tj
4.6985 0 Td
(are)Tj
1.6583 0 Td
(highlighted)Tj
5.0173 0 Td
(in)Tj
0.9993 0 Td
(grey.)Tj
2.4449 0 Td
(Putative)Tj
3.8197 0 Td
(function)Tj
3.7063 0 Td
(and)Tj
1.8851 0 Td
(results)Tj
3.1606 0 Td
(of)Tj
1.0559 0 Td
(BlastP)Tj
3.1111 0 Td
(comparis)Tj
4.0252 0 Td
(on)Tj
1.3323 0 Td
(\(E)Tj
-65.6792 -1.4953 Td
(value)Tj
2.6008 0 Td
(and)Tj
1.8779 0 Td
(%)Tj
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(protein)Tj
3.2599 0 Td
(identity\))Tj
3.7134 0 Td
(with)Tj
/F8 1 Tf
1.9914 0 Td
(Mah)Tj
/F0 1 Tf
(104)Tj
3.8126 0 Td
(and)Tj
/F8 1 Tf
1.8851 0 Td
(Mah)Tj
/F0 1 Tf
2.1614 0 Td
(TH135)Tj
3.2102 0 Td
(genom)Tj
3.0261 0 Td
(e.)Tj
/F11 1 Tf
-0.005 Tc
-28.6514 -2.2535 Td
(doi:)Tj
-0.025 Tc
(10.137)Tj
4.0323 0 Td
(1/journal.pone.)Tj
5.5559 0 Td
(0171895.t)Tj
3.7914 0 Td
(002)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
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