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Case report of a false positive result of the Xpert MTB/RIF assay for rifampicin resistance in mycobacterium tuberculosis complex

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1179/2295333715Y.0000000072 [1]

Authors

Claessens,J. [2]; Vanessa Mathys [3]; Derdelinckx,I. [4]; Saegeman,V. [5]

Keywords

  1. a [6]
  2. Abdomen [7]
  3. article [8]
  4. AS [9]
  5. Case [10]
  6. conventional [11]
  7. culture [12]
  8. detection [13]
  9. Diagnosis [14]
  10. DRUG [15]
  11. health [16]
  12. INFECTION [17]
  13. IS [18]
  14. IT [19]
  15. journal [20]
  16. Microscopy [21]
  17. Molecular [22]
  18. Mycobacterium [23]
  19. Mycobacterium tuberculosis [24]
  20. old [25]
  21. ON [26]
  22. organisation [27]
  23. Patient [28]
  24. present [29]
  25. Print [30]
  26. report [31]
  27. resistance [32]
  28. result [33]
  29. results [34]
  30. specificity [35]
  31. Test [36]
  32. TESTING [37]
  33. tests [38]
  34. Tuberculosis [39]
  35. use [40]
  36. Version [41]
  37. WHO [42]
  38. world [43]
  39. World Health [44]

Abstract:

In the present case, we report a false positive result for the detection of rifampicin (RIF) resistance by the Xpert(R) MTB/RIF assay, version G4.Miliary Mycobacterium tuberculosis infection (miliary TB) was suspected in a 50-year old Angolan woman. Imaging of the thorax and abdomen displayed diffuse lesions. The Xpert(R) MTB/RIF assay conducted on the broncho-alveolar lavage (BAL) fluid was positive for TB and positive for RIF resistance. Confirmatory molecular tests and the phenotypic drug susceptibility determination supported the diagnosis of TB but not RIF resistance. The patient was t…
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Source URL:https://www.sciensano.be/en/biblio/case-report-a-false-positive-result-xpert-mtb-rif-assay-rifampicin-resistance-mycobacterium

Links
[1] http://dx.doi.org/10.1179/2295333715Y.0000000072 [2] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=1710&f%5Bsearch%5D=Claessens%2CJ. [3] https://www.sciensano.be/en/people/vanessa-mathys/biblio [4] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=20976&f%5Bsearch%5D=Derdelinckx%2CI. [5] https://www.sciensano.be/en/biblio?f%5Bauthor%5D=20979&f%5Bsearch%5D=Saegeman%2CV. [6] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1029&f%5Bsearch%5D=a [7] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=18465&f%5Bsearch%5D=Abdomen [8] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=618&f%5Bsearch%5D=article [9] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=846&f%5Bsearch%5D=AS [10] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1518&f%5Bsearch%5D=Case [11] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=3012&f%5Bsearch%5D=conventional [12] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1497&f%5Bsearch%5D=culture [13] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=540&f%5Bsearch%5D=detection [14] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1338&f%5Bsearch%5D=Diagnosis [15] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=3015&f%5Bsearch%5D=DRUG [16] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=888&f%5Bsearch%5D=health [17] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1578&f%5Bsearch%5D=INFECTION [18] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=525&f%5Bsearch%5D=IS [19] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1200&f%5Bsearch%5D=IT [20] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2190&f%5Bsearch%5D=journal [21] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=4110&f%5Bsearch%5D=Microscopy [22] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1059&f%5Bsearch%5D=Molecular [23] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2697&f%5Bsearch%5D=Mycobacterium [24] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2769&f%5Bsearch%5D=Mycobacterium%20tuberculosis [25] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1872&f%5Bsearch%5D=old [26] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=912&f%5Bsearch%5D=ON [27] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1788&f%5Bsearch%5D=organisation [28] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=723&f%5Bsearch%5D=Patient [29] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=3132&f%5Bsearch%5D=present [30] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2379&f%5Bsearch%5D=Print [31] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2388&f%5Bsearch%5D=report [32] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1674&f%5Bsearch%5D=resistance [33] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1098&f%5Bsearch%5D=result [34] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1101&f%5Bsearch%5D=results [35] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2550&f%5Bsearch%5D=specificity [36] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=936&f%5Bsearch%5D=Test [37] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1773&f%5Bsearch%5D=TESTING [38] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2220&f%5Bsearch%5D=tests [39] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=2712&f%5Bsearch%5D=Tuberculosis [40] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=567&f%5Bsearch%5D=use [41] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=18468&f%5Bsearch%5D=Version [42] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=1593&f%5Bsearch%5D=WHO [43] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=942&f%5Bsearch%5D=world [44] https://www.sciensano.be/en/biblio?f%5Bkeyword%5D=3711&f%5Bsearch%5D=World%20Health