Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains36636
Public Access
Published
Peer reviewed scientific article
SCIENSANO
Auteurs
R. Vanhoof [1]; Hubrechts,J.M. [2]; Nyssen,H.J. [3]; Nulens,E. [4]; Leger,J. [5]; de Schepper,N. [6]; Kupperberg,E. [7]; Couvreur,M.L. [8]Trefwoorden
Samenvatting:
By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration greater than or equal to 8 mg/l) or resistant (minimal inhibiting concentration greater than or equal to 64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam-mecillinam showed the highest rate of syn…