Amidst the COVID-19 pandemic, the sentinel surveillance resumed slowly in the season 2020-2021. Only the severe acute respiratory infections (SARI) allowed to properly evaluate the circulation of respiratory viruses during the 2020-2021 season. The season was characterized by the absence of an influenza virus epidemic, and the return of parainfluenza viruses and respiratory syncytial viruses detected mainly in children. SARS-CoV-2 continued to intensively circulate and was mainly detected in adults and older adults. Other respiratory viruses such as metapneumoviruses, seasonal coronaviruses, rhino- and enteroviruses, and adenoviruses were also detected, without clear epidemic wave.