A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa.
Ziekten en gezondheid in kaart brengen
Downloaden 4.39 MBAuteurs
Sandra Van Puyvelde [3]; Tessa de Block [4]; Sushmita Sridhar [5]; Matt Bawn [6]; Robert A Kingsley [7]; Brecht Ingelbeen [8]; Mathew A Beale [9]; Barbé, Barbara [10]; Jeon, Hyon Jin [11]; Lisette Mbuyi-Kalonji [12]; Phoba, Marie-France [13]; Falay, Dadi [14]; Martiny, Delphine [15]; Vandenberg, Olivier [16]; Affolabi, Dissou [17]; Jean Pierre Rutanga [18]; Pieter-Jan Ceyssens [19]; Wesley Mattheus [20]; Wim L Cuypers [21]; Marianne A B van der Sande [22]; Park Se Eun [23]; Simon Kariuki [24]; Kephas Otieno [25]; John P A Lusingu [26]; Joyce R Mbwana [27]; Samuel Adjei [28]; Anima Sarfo [29]; Seth O Agyei [30]; Kwaku P Asante [31]; Walter Otieno [32]; Lucas Otieno [33]; Marc C Tahita [34]; Lompo, Palpouguini [35]; Irving F Hoffman [36]; Mvalo, Tisungane [37]; Msefula, Chisomo [38]; Fatimah Hassan-Hanga [39]; Stephen Obaro [40]; Grant Mackenzie [41]; Stijn Deborggraeve [42]; Nicholas Feasey [43]; Florian Marks [44]; Calman A MacLennan [45]; Nicholas R Thomson [46]; Jacobs, Jan [47]; Gordon Dougan [48]; Samuel Kariuki [49]; Lunguya, Octavie [50]Trefwoorden
Samenvatting:
Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa’s most impacted countries. At least six…