Search results - 27 results
2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.
dialkyltetrahydrobenzo[g]pyrimido [4,5-c]isoquinolinetetraones were designed and synthesised. The compounds were submitted to a biological evaluation in which the activity against M.tb H37R v(lux) was observed, as well as the acute ...
1,2,3,4,8,9,10,11-Octahydrobenzo[j]phenanthridine-7,12-diones as New Leads against Mycobacterium tuberculosis
Mycobacterium tuberculosis was demonstrated. Next to the acute toxicity, the genotoxicity of these compounds was investigated. Often overlooked in studies, genotoxicity could be dismissed for the investigated ...
Biological evaluation of diazene derivatives as anti-tubercular compounds.
examined for acute cell toxicity on a murine macrophage like monocyte cell line J774 A.1 in which the cell viability was reduced by 50% at concentrations ranging from 7.4 μg/mL to 20.7 μg/mL. Neither of the ...
Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine36497
Eur.J.Med.Chem., Volume 67, Number 110, p.98- 110 (2013) Keywords: acute toxicity antibiotics Cleistopholine Pyridinium ylids Sampangine Tuberculosis Abstract: Identification and investigation of novel classes and ...
Scientific Opinion of the EFSA Panel on Plant Protection Products and their Residues (PPR) on Evaluation of the toxicological relevance of pesticide metabolites for dietary risk assessment
for genotoxic and toxic compounds were found to be sufficiently conservative for chronicexposure, as a result of a validation study with a group of pesticides belonging to different chemicalclasses. ...
Anti-TNF-alpha therapy does not ameliorate disease in a model of acute virus-endotoxin mediated respiratory disease in pigs36852
Keywords: 0 a Activity acute Acute Disease ALL analysis Animal Animals antagonists & inhibitors article AS at Autoimmune Diseases Belgium Bronchoalveolar Lavage Fluid Cell Clinical conditions Control ...
Clinical and pharmacological evaluation of different preparations of oral erythromycin36591
p.367- 372 (1979) Keywords: 0 a Activity acute administration & dosage Administration,Oral Adult analogs & derivatives Antibiotic article at blood Bronchitis chronic Chronic-bronchitis Clinical ...