A multifaceted study of Pseudomonas aeruginosa shutdown by virulent podovirus LUZ19

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

English

Abstract:

In contrast to the rapidly increasing knowledge on genome content and diversity of bacterial viruses, insights in intracellular phage development and its impact on bacterial physiology are very limited. We present a multifaceted study combining quantitative PCR (qPCR), microarray, RNA-seq, and two-dimensional gel electrophoresis (2D-GE), to obtain a global overview of alterations in DNA, RNA, and protein content in Pseudomonas aeruginosa PAO1 cells upon infection with the strictly lytic phage LUZ19. Viral genome replication occurs in the second half of the phage infection cycle and coincide…

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