A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds.

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Pre-print

Peer reviewed scientific article

English

Abstract:

Asthma is a serious health problem and during the last decade various experimental models of asthma have been developed to study the pathogenesis of this disease. In this study we describe a new mouse model of asthma that uses the spores of Alternaria alternata and Cladosporium herbarum, two allergenic molds recognized as common inducers of rhinitis and asthma in humans. Here we demonstrate that A. alternata and C. herbarum spores are immunogenic when injected into BALB/c mice, and induce the production of specific IgM and IgG1 antibodies and strongly increase IgE serum levels. To induce th…

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