Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

Last updated on 20-1-2021 by Jill Alexandre

Public Access


Peer reviewed scientific article



Background: The terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, …

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