Attenuation of RNA viruses by redirecting their evolution in sequence space.

Last updated on 3-6-2020 by Anonymous (not verified)

Peer reviewed scientific article

English

SCIENSANO

Abstract:

RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their evolutionary potential. We rationally altered the genomes of Coxsackie B3 and influenza A viruses to redirect their evolutionary trajectories towards detrimental regions in sequence space. Specifically, viral genomes were engineered to harbour more serine and leucine codons with nonsense mutation targets: codons that could generate Stop mutations after a singl…

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